P 75 Long-term results of Alzheimer's and Parkinson's disease after Transcranial Pulse Stimulation (TPS) of the brain with focused extracorporeal shock waves (ESW)

• Published in: Clinical neurophysiology Vol. 137; pp. e58 - e59
• Main Author: Lohse-Busch, H.
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.05.2022
• ISSN: 1388-2457; 1872-8952
• DOI: 10.1016/j.clinph.2022.01.106

Introduction: The introduction of an ESW generator with navigation system (Neurolith, Storz Medical) is a breakthrough for the precise treatment of brain structures. It enabled the targeted TPS for Alzheimer’s patients (1). After a treatment series with TPS, Alzheimer’s patients showed after 3 months not only a significant functional gain in cognitive abilities but also a partial repair of cortical areas responsible for memory functions (3). Now case histories will be presented with long-term observations of patients with Alzheimer's and Parkinson's disease treated with TPS as a critical endeavor for future treatments. Methods: 6 patients with mild Alzheimer’s disease (Mini mental status >18) were treated initially 6 times during 2 weeks with TPS. After this, the patients received one TPS session monthly over 3 years. The results were assessed with the CERAD Plus score and compared with the data of the natural development to be expected for these patients (2). Results: During a steady enhancement of the cognitive abilities over 12 months of 12 %, the results diminished during the second year back to the baseline. A two weeks booster with TPS like the initial treatment enhanced the results again with 4,5 %. After 3 years the results were on the level of the natural history. 4 patients with Parkinson’s disease received TPS after the aforementioned protocol but had every twelve months a booster (6 sessions in 2 weeks). After the initial treatment block with TPS their symptoms improved by roughly 50% (Unified Parkinson Rating Scale) and remained stable until to date for over 4 years and in one patient for 8 years. Conclusion: It is conceivable that more frequent testing and earlier boosters would also achieve a better result in Alzheimer's patients. References: 1. Beisteiner R, Matt E, et alii (2019) Transcranial Pulse Stimulation with Ultrasound in Alzheimer’s Disease—A New Navigated Focal Brain Therapy. Adv Sci (Weinh) 23;7(3):1902583. 2. Hallikainen, I.; Hänninen, T. et alii Progression of Alzheimer's disease during a three-year follow-up using the CERAD-NB total score: Kuopio ALSOVA study, International Psychogeriatrics,Cambridge Univ Press,2013, 25, 1335-1344. 3. Popescu T, Pernet C, et alii R (2021) Transcranial ultrasound pulse stimulation reduces cortical atrophy in Alzheimer’s patients: A follow-up study. Alzheimer’s Dement. 2021;7:e12121.