151-P

• Published in: Human immunology Vol. 74; p. 153
• Main Authors: Partida-Rodriguez, Oswaldo, Hernandez, Eric G, Maldonado, Carmen, Valenzuela, Olivia, Magaña, Ulises J.C, Rascón, Edgar, Nieves-Ramirez, Miriam E, Valadez, Alicia, Zermeño, Valeria, Cerritos, Rene, Portillo, Tobias, Rojas, Liliana, Gonzalez, Enrique, Moran, Patricia, Ximenez, Cecilia
• Format: Journal Article
• Language: English
• Published: 01.11.2013
• Subjects: Allergy and Immunology
• ISSN: 0198-8859
• DOI: 10.1016/j.humimm.2013.08.226

Aim Toll-Like Receptors (TLRs) recognize Entamoeba histolytica molecular patterns generating a series of intracellular signaling that leads to the modulation of the innate immune system. Single nucleotide polymorphisms (SNPs) in TLR genes may influence their activity. We studied associations of TLRs SNPs with susceptibility to develop amoebic liver abscess (ALA) by Entamoeba histolytica in Mexican individuals from the State of Sonora and from Mexico City (DF). Methods We typed by allelic exclusion the SNPs R677W and R753Q of TLR2, D299G and T399I of TLR4, and -1237T/C and 2848G/A of TLR9. We compared SNPs frequencies of ALA patients (Sonora n=32, DF n=32) with control individuals (Sonora n=58, DF n=21). Results The genotype TLR9 2848G/A in ALA patients from DF showed a statistically (p=0.008) increased frequency (63.3%) when compared with controls (25.0%), with an OR of 5.18 (95% CI 1.27-22.37). Conclusions We will increase sample size in order to find out if the TLR9 2848G/A can be considered as a marker of susceptibility to ALA in population from the center of Mexico. Work partially supported by PAPIIT IN206408, IN206405, PAPIME 200105 and SEP-CONACYT 79220.