Role of superoxide dismutase in acute pancreatitis: from antioxidant protection to gene regulation

We present modern data on the role of superoxide dismutase (SOD) in antioxidant protection and gene regulation in acute pancreatitis. Antioxidant enzymes are essential in pathogenesis of numerous diseases. SOD is one of the key enzymes of antioxidant system. In this review, we analyzed activity of t...

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Bibliographic Details
Published inHirurgija (Moskva) no. 4; p. 112
Main Authors Dunaevskaya, S S, Sergeeva, E Yu, Titova, N M, Fefelova, Yu A, Deulina, V V
Format Journal Article
LanguageRussian
Published Russia (Federation) 2024
Subjects
Acute Disease
Antioxidants
Humans
Pancreatitis
Superoxide Dismutase - genetics
Superoxide Dismutase - metabolism
antioxidant protection
superoxide dismutase
acute pancreatitis
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Summary:We present modern data on the role of superoxide dismutase (SOD) in antioxidant protection and gene regulation in acute pancreatitis. Antioxidant enzymes are essential in pathogenesis of numerous diseases. SOD is one of the key enzymes of antioxidant system. In this review, we analyzed activity of this enzyme depending on various factors, mechanisms and role in physiological and pathological processes, in particular, acute pancreatitis. SOD is significantly less active in patients with severe acute pancreatitis accompanied by renal failure, severe circulatory disorders and high mortality. There are some SOD gene polymorphisms, in particular, acute destructive pancreatitis R213G, contributing to acute inflammation. Thus, SOD is not only one of the key antioxidant enzymes, but also potential transcription factor regulating activity of signaling pathways. These aspects can underlie new therapies for diseases.
ISSN:0023-1207
DOI:10.17116/hirurgia2024041112