Cellulose acetate-based electrospun nanocomposites improved by mussel-inspired polydopamine coatings and copper iodide-decorated graphene oxide: A self-disinfecting nanofibrous membrane with potential biomedical applications

• Published in: Inorganic chemistry communications Vol. 170; p. 113181
• Main Authors: Avatefi, Manizheh, Moghadam, Negin Borzooee, Asghari, Sahar, Bakhshesh, Mehran, Kruppke, Benjamin, Khonakdar, Hossein Ali, Alamdaran, Fatemeh Sadat, Ekrami, Elena, Mahmoudifard, Matin
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.12.2024
• Subjects: Antimicrobial nanocomposite; Cellulose acetate; Copper iodide; Electrospun nanofiber; Graphene oxide; Mussle inspired poly dopamine; Electrospun nanofiber; Mussle inspired poly dopamine; Graphene oxide; Antimicrobial nanocomposite; Cellulose acetate; Copper iodide
• ISSN: 1387-7003
• DOI: 10.1016/j.inoche.2024.113181

[Display omitted] •Copper iodide (CuI) decorated graphene nanocomposite was synthesized through a green water-based procedure.•A novel nanofibrous membrane with improved antimicrobial characteristics was prepared by a mussel-inspired surface engineering method.•Polydopamine and CuI-decorated graphene oxide (GO-CuI) nanoparticles were coated on cellulose electrospun nanofibers.•Results showed that the surface functionalization of nanofibrous membrane with GO-CuI nanocomposite can directly improve the antimicrobial properties. Personal protective equipment and fabrics have proven their efficient use in the SARS-CoV-2 pandemic, but because germs and viruses may survive on them, they can also operate as a source of disease transmission. Self-disinfecting textiles with the potential to kill different pathogens can be used as a substitute and prevent infections. In this research, copper iodide (CuI) decorated graphene oxide nanocomposite was synthesized through a green water-based procedure, and a novel nanofibrous membrane with improved antibacterial and antiviral characteristics was prepared by a mussel-inspired method, in which polydopamine (DOPA) and CuI-decorated graphene oxide (GO-CuI) nanocomposite were coated on cellulose acetate electrospun nanofibers (CA-DOPA-GOCuI). CA-DOPA-GOCuI NFM displayed extremely good antibacterial/antiviral properties with biofilm inhibition of 50 %, and very good cell viability and proliferation even though the virus was introduced to the cell culture. Furthermore, because it accelerated the healing process, this NFM showed great promise for use as a wound dressing. This may be because it inhibits infection and has an extremely high ROS scavenging capability of 80 %. Additionally, it was shown that CA-DOPA-GOCuI NFM was non-toxic to cells and blood compatible, with cell viability that was even higher than that of the control group of untreated cells. One possible explanation for this could be the inclusion of GO, a highly biocompatible member of the graphene family, which, when combined with CuI, reduced its toxicity to normal cells. Thus, the safety of CA-DOPA-GOCuI to normal cells, favorable cell proliferation and viability, and its high toxicity to bacteria and viruses indicate its great potential to be used in a wide range of biomedical applications, specifically, self-disinfecting fabrics and wound dressings.