67 THE USE OF COMPUTED TOMOGRAPHIC CORONARY ANGIOGRAPHY IN THE ASSESSMENT OF PLAQUE TYPE AND ITS RELATIONSHIP TO DEGREE OF STENOSIS AND GENDER

BackgroundThe Glagov hypothesis suggests that positive remodeling preserves lumen size until further plaque formation results in significant narrowing. However, there are no data relating the percent stenosis (%S) to the plaque type and its relationship to patient's gender.MethodsFifty patients...

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Bibliographic Details
Published inJournal of investigative medicine Vol. 55; no. 1; p. S258
Main Authors Gottsegen, J., Prakash, M., Lubarsky, L., Coplan, N., Hecht, H.
Format Journal Article
LanguageEnglish
Published London Sage Publications Ltd 01.01.2007
Subjects
Calcification
Medical imaging
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Summary:BackgroundThe Glagov hypothesis suggests that positive remodeling preserves lumen size until further plaque formation results in significant narrowing. However, there are no data relating the percent stenosis (%S) to the plaque type and its relationship to patient's gender.MethodsFifty patients undergoing 64-detector computed tomographic angiography (CTA) were evaluated using the AHA 18 segment model. Stenoses were assigned to quartiles: 0 to 25%, 25 to 50%, 50 to 75%, and > 75%. Plaque was characterized as totally noncalcified (TNC), predominantly nonC (PNC), predominantly C (PC), and totally C (TC).ResultsThere was a significant (p < .01) direct relationship between the extent of noncalcified plaque and the %S. The association was statistically significant for women but not for men (p < .01 and p = .2, respectively; Table).Conclusions(1) There is a significant association between vessel lumen and calcification in females but not in males. (2) Noncalcified plaque is directly, and calcified plaque inversely, related to the severity of arterial narrowing; this suggests that positive remodeling associated with predominantly calcified plaque preserves lumen size.
ISSN:1081-5589
1708-8267