Interactions between the gut microbiome and mucosal immunoglobulins A, M and G in the developing infant gut

• Published in: bioRxiv
• Main Authors: Janzon, Anders, Goodrich, Julia K, Koren, Omry, The Teddy Study Group, Waters, Jillian, Ley, Ruth
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 15.05.2019; Cold Spring Harbor Laboratory
• Edition: 1.1
• Subjects: Age; Breast feeding; Breastfeeding & lactation; Coatings; Enterobacteriaceae; Flow cytometry; Immunoglobulin A; Immunoglobulin G; Immunoglobulin M; Infants; Intestinal microflora; Microbiology; Microbiota; Mucosa; rRNA 16S; IgA; gut microbiome; infant gut development; antibody coating; IgG; FACS; IgM

Objective: Interactions between the gut microbiome and immunoglobulin (Ig) A in infancy are important for future health. IgM and IgG are also present, however, their interactions with the microbiome in the developing infant are less understood. Design: We employed stool samples sampled 15 times in i...