Prevalence of angina pectoris and association with coronary atherosclerosis in a general population

• Published in: Heart (British Cardiac Society) Vol. 109; no. 19; pp. 1450 - 1459
• Main Authors: Welén Schef, Kerstin, Tornvall, Per, Alfredsson, Joakim, Hagström, Emil, Ravn-Fischer, Annica, Soderberg, Stefan, Yndigegn, Troels, Jernberg, Tomas
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group Ltd and British Cardiovascular Society 2023; BMJ Publishing Group LTD; BMJ Publishing Group
• Series: Original research
• Subjects: Angina pectoris; Atherosclerosis; Body mass index; Cardiac and Cardiovascular Systems; Cardiovascular disease; Cholesterol; Clinical Medicine; computed tomography angiography; Contrast agents; Coronary Artery Disease; Coronary vessels; Cross-sectional studies; epidemiology; Investigations; Kardiologi; Klinisk medicin; Medical and Health Sciences; Medical imaging; Medicin och hälsovetenskap; Middle age; Pain; Questionnaires; Sociodemographics; Variables; Vein & artery diseases; atherosclerosis; coronary artery disease; epidemiology; computed tomography angiography; angina pectoris
• ISSN: 1355-6037; 1468-201X; 1468-201X
• DOI: 10.1136/heartjnl-2023-322345

ObjectiveTo assess the contemporary prevalence of, and factors associated with angina pectoris symptoms, and to examine the relationship to coronary atherosclerosis in a middle-aged, general population.MethodsData were based on the Swedish CArdioPulmonary bioImage Study (SCAPIS), in which 30 154 individuals were randomly recruited from the general population between 2013 and 2018. Participants that completed the Rose Angina Questionnaire were included and categorised as angina or no angina. Subjects with a valid coronary CT angiography (CCTA) were categorised by degree of coronary atherosclerosis; ≥50% obstruction (obstructive coronary atherosclerosis), <50% obstruction or any atheromatosis (non-obstructive coronary atherosclerosis) or none (no coronary atherosclerosis).ResultsThe study population consisted of 28 974 questionnaire responders (median age 57.4 years, female 51.6%, hypertension 19.9%, hyperlipidaemia 7.9%, diabetes mellitus 3.7%), of which 1025 (3.5%) fulfilled the criteria of angina. Coronary atherosclerosis was more common in individuals having angina compared with those with no angina (n=24 602, obstructive coronary atherosclerosis 11.8% vs 5.4%, non-obstructive coronary atherosclerosis 38.9% vs 37.0%, no coronary atherosclerosis 49.4% vs 57.7%, all p<0.001). Factors independently associated with angina were birthplace outside of Sweden (OR 2.58 (95% CI 2.10 to 2.92)), low educational level (OR 1.41 (1.10 to 1.79)), unemployment (OR 1.51 (1.27 to 1.81)), poor economic status (OR 1.85 (1.38 to 2.47)), symptoms of depression (OR 1.63 (1.38 to 1.92)) and high degree of stress (OR 2.92 (1.80 to 4.73)).ConclusionAngina pectoris symptoms are common (3.5%) among middle-aged individuals of the general population of Sweden, though with low association to obstructive coronary atherosclerosis. Sociodemographic and psychological factors are highly associated with angina symptoms, irrespective of degree of coronary atherosclerosis.