Improving Whole-Brain Neural Decoding of fMRI with Domain Adaptation

• Published in: bioRxiv
• Main Authors: Zhou, Shuo, Cox, Christopher R, Lu, Haiping
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 07.08.2018; Cold Spring Harbor Laboratory
• Edition: 1.2
• Subjects: Brain mapping; Cognitive ability; Functional magnetic resonance imaging; Learning algorithms; Neural coding; Neuroimaging; Neuroscience; Whole-brain fMRI; neural decoding; classification; domain adaptation; machine learning
• ISSN: 2692-8205; 2692-8205
• DOI: 10.1101/375030

In neural decoding, there has been a growing interest in machine learning on whole-brain functional magnetic resonance imaging (fMRI). However, the size discrepancy between the feature space and the training set poses serious challenges. Simply increasing the number of training examples is infeasible and costly. In this paper, we proposed a domain adaptation framework for whole-brain fMRI (DawfMRI) to improve whole-brain neural decoding on target data leveraging pre-existing source data. DawfMRI consists of three steps: 1) feature extraction from whole-brain fMRI, 2) source and target feature adaptation, and 3) source and target classifier adaptation. We evaluated its eight possible variations, including two non-adaptation and six adaptation algorithms, using a collection of seven task-based fMRI datasets (129 unique subjects and 11 cognitive tasks in total) from the OpenNeuro project. The results demonstrated that appropriate source domain can help improve neural decoding accuracy for challenging classification tasks. The best-case improvement is 8.94% (from 78.64% to 87.58%). Moreover, we discovered a plausible relationship between psychological similarity and adaptation effectiveness. Finally, visualizing and interpreting voxel weights showed that the adaptation can provide additional insights into neural decoding. Footnotes * Section 2.3.1, 4.1, and 4.2 updated to clarify. Figure captions updated to clarify. Figure 8 revised.