Increase in transmitted resistance to non-nucleoside reverse transcriptase inhibitors among newly diagnosed HIV-1 infections in Europe

• Published in: BMC infectious diseases Vol. 14; no. 1; p. 407
• Main Authors: Frentz, Dineke, Van de Vijver, David A M C, Abecasis, Ana B, Albert, Jan, Hamouda, Osamah, Jørgensen, Louise B, Kücherer, Claudia, Struck, Daniel, Schmit, Jean-Claude, Vercauteren, Jurgen, Åsjö, Birgitta, Balotta, Claudia, Beshkov, Danail, Camacho, Ricardo J, Clotet, Bonaventura, Coughlan, Suzie, Griskevicius, Algirdas, Grossman, Zehava, Horban, Andrzej, Kolupajeva, Tatjana, Korn, Klaus, Kostrikis, Leondios G, Liitsola, Kirsi, Linka, Marek, Nielsen, Claus, Otelea, Dan, Paraskevis, Dimitrios, Paredes, Roger, Poljak, Mario, Puchhammer-Stöckl, Elisabeth, Sönnerborg, Anders, Stanekova, Danica, Stanojevic, Maja, Van Wijngaerden, Eric, Wensing, Annemarie M J, Boucher, Charles A B
• Format: Journal Article Web Resource
• Language: English
• Published: England BioMed Central Ltd 21.07.2014; BioMed Central
• Subjects: Acquired immune deficiency syndrome; Adult; AIDS; Analysis; Anti-HIV Agents - therapeutic use; Drug resistance; Drug Resistance, Viral; Drug therapy; Epidemiology; Ethics; Europe; Europe - epidemiology; Female; Genotype; Grants; Health aspects; HIV; HIV Infections - drug therapy; HIV Infections - epidemiology; HIV Infections - transmission; HIV Infections - virology; HIV-1; HIV-1 - classification; HIV-1 - drug effects; HIV-1 - genetics; HIV-1 - isolation & purification; Hospitals; Human health sciences; Human immunodeficiency virus; Human immunodeficiency virus 1; Humans; Immunologie & maladie infectieuse; Immunology & infectious disease; Infections; Laboratories; Male; Medicin och hälsovetenskap; Mortality; Mutation; Phylogenetics; Phylogeny; Prevalence; Public health; Resistance; Sciences de la santé humaine; Studies; Transmission; Virology; Europe; Israel; Western Europe; Latvia; Luxembourg
• ISSN: 1471-2334; 1471-2334
• DOI: 10.1186/1471-2334-14-407

One out of ten newly diagnosed patients in Europe was infected with a virus carrying a drug resistant mutation. We analysed the patterns over time for transmitted drug resistance mutations (TDRM) using data from the European Spread program. Clinical, epidemiological and virological data from 4317 patients newly diagnosed with HIV-1 infection between 2002 and 2007 were analysed. Patients were enrolled using a pre-defined sampling strategy. The overall prevalence of TDRM in this period was 8.9% (95% CI: 8.1-9.8). Interestingly, significant changes over time in TDRM caused by the different drug classes were found. Whereas nucleoside resistance mutations remained constant at 5%, a significant decline in protease inhibitors resistance mutations was observed, from 3.9% in 2002 to 1.6% in 2007 (p = 0.001). In contrast, resistance to non-nucleoside reverse transcriptase inhibitors (NNRTIs) doubled from 2.0% in 2002 to 4.1% in 2007 (p = 0.004) with 58% of viral strains carrying a K103N mutation. Phylogenetic analysis showed that these temporal changes could not be explained by large clusters of TDRM. During the years 2002 to 2007 transmitted resistance to NNRTI has doubled to 4% in Europe. The frequent use of NNRTI in first-line regimens and the clinical impact of NNRTI mutations warrants continued monitoring.