AB0825 Gender Specific Differences in Patients with Psoriatic Arthritis

• Published in: Annals of the rheumatic diseases Vol. 74; no. Suppl 2; p. 1176
• Main Authors: Nas, K., Capkin, E., Dagli, A.Z., Cevik, R., Kilic, E., Kilic, G., Karkucak, M., Durmus, B., Ozgocmen, S.
• Format: Journal Article
• Language: English
• Published: London BMJ Publishing Group LTD 01.06.2015
• ISSN: 0003-4967; 1468-2060
• DOI: 10.1136/annrheumdis-2015-eular.5654

BackgroundPsoriatic arthritis (PsA) has been defined as an inflammatory arthritis associated with psoriasis. Gender specific differences regarding the clinical picture and burden of the disease is unclear in PsA.ObjectivesTo assess gender related differences in a cohort of patients with PsA.MethodsConsecutively recruited patients (from five university hospitals) who met CASPAR criteria, age more than18 years were included and underwent clinical, radiological and laboratory evaluation by using standardized protocol and case report forms.ResultsA total of 187 patients with PsA (72 male; 115 female) were analyzed. Women with PsA had higher symptom duration (beginning of articular symptoms) and body mass index (BMI), tender and swollen joint counts, disease activity score-28 joints (DAS28), ESR, physical activity and fatigue component scores of Nottingham Health Profile (NHP) scores than men with PsA (Table). Psoriasis area and severity index (PASI) was higher in male patients. However quality of life (SF36 physical and mental component scores) and psychological distress measures were quite similar between men and women. Some of the extra-articular features (including uveitis, iritis) and family history for psoriasis, PsA and ankylosing spondylitis did not differ between genders. Articular involvement patterns were not different between men and women (in %, asymmetrical oligoarthritis 51.4 vs 48.7, symmetrical polyarthritis 15.3 vs 17.4, DIP 6.9 vs 13.9, arthritis mutilans 5.6 vs 5.2, axial 20.8 vs 14.8, respectively, p=0.547).Table 1Male (n=72)Female (n=115)pmean ± SDmean ± SDAge43.8±13.641.9±11.60.309BMI25.9±3.828.5±7.00.001Symptom duration, years7.5±6.810.2±9.10.023Diagnostic delay, years1.3±2.41.9±5.80.314Duration psoriasis-arthritis, months111.0±113.572.1±80.00.014Pain-VAS4.3±6.04.6±2.60.647Patient's global4.4±4.14.6±2.80.751Tender joint count4.6±7.98.2±10.80.010Swollen joint count0.9±1.72.0±4.40.015PASI15.8±21.28.3±11.90.035DAS28-CRP3.1±1.44.0±1.6<0.0001ESR (mm/h)18.6±19.026.2±19.10.009CRP (mg/l)7.3±11.56.9±11.50.811Duruoz Hand Index (DHI)6.1±13.69.9±14.80.079NHP-physical activity24.7±21.832.7±27.70.032NHP-fatigue30.0±37.749.4±41.60.001HAD-depression6.9±4.06.8±3.90.829HAD-anxiety6.3±4.06.4±4.50.844PsAQoL5.8±5.56.5±5.90.423ConclusionsSome of the clinical and laboratory variables tent to be different between men and women with PsA. The extent of psychological distress, pain, quality of life and pattern of joint involvement tent to be similar in both genders. Men with PsA are more likely to have higher PASI scores and longer duration to develop arthritis after the onset of psoriasis, while women are more likely to have higher disease activity and report more fatigue and physical activity limitations.Disclosure of InterestNone declared