Echinococcus granulosus infection reduces airway inflammation of mice likely through enhancing IL-10 and down-regulation of IL-5 and IL-17A

• Published in: Parasites & vectors Vol. 7; no. 1; p. 522
• Main Authors: Wang, Hui, Li, Jun, Pu, Hongwei, Hasan, Bilal, Ma, Jinfeng, Jones, Malcolm K, Zheng, Kan, Zhang, Xue, Ma, Haimei, McManus, Donald P, Lin, Renyong, Wen, Hao, Zhang, Wenbao
• Format: Journal Article
• Language: English
• Published: England Springer-Verlag 20.11.2014; BioMed Central Ltd; BioMed Central; BMC
• Subjects: Albumin; Allergic asthma; Allergies; Animals; Asthma; blood serum; Chinese medicine; Cystic echinococcosis; Cysts; Cytokines; dogs; echinococcosis; Echinococcosis - metabolism; Echinococcosis - parasitology; Echinococcus granulosus; enzyme-linked immunosorbent assay; Eosinophils; Epidemiology; Female; Gene Expression Regulation; goblet cells; Health aspects; histopathology; Hospitals; hyperplasia; IL-10; IL-17A; IL-5; Immune response; immunoglobulins; Infections; inflammation; Inflammation - metabolism; interleukin-10; Interleukin-10 - genetics; Interleukin-10 - metabolism; Interleukin-17 - genetics; Interleukin-17 - metabolism; interleukin-5; Interleukin-5 - genetics; Interleukin-5 - metabolism; intermediate hosts; Laboratory animals; larvae; lungs; Mice; Mice, Inbred BALB C; mucus; ovalbumin; Ovalbumin - toxicity; Pathology; pneumonia; Public health; Respiratory Tract Infections - metabolism; reverse transcriptase polymerase chain reaction; Rodents; Specific Pathogen-Free Organisms; Studies; tapeworms; zoonoses; Queensland Australia

BACKGROUND: Cystic echinococcosis (CE) is a near cosmopolitan zoonosis caused by the larval stage of the dog tapeworm Echinococcus granulosus. E. granulosus infection induces a polarized T-helper type 2 (Th2) systematic immune response in its intermediate hosts. However, it is not known whether the...