Microbial production of hyaluronic acid: current state, challenges, and perspectives

• Published in: Microbial cell factories Vol. 10; no. 1; p. 99
• Main Authors: Liu, Long, Liu, Yanfeng, Li, Jianghua, Du, Guocheng, Chen, Jian
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 16.11.2011; BioMed Central; BMC
• Subjects: Acids; Bacteria; Biocompatibility; Colleges & universities; Cosmetics; Disaccharides; Fermentation; Functional foods & nutraceuticals; Glucosamine; History, 20th Century; History, 21st Century; Hyaluronic acid; Hyaluronic Acid - biosynthesis; Hyaluronic Acid - chemistry; Industrial Microbiology - history; Industrial Microbiology - trends; Metabolic engineering; Metabolites; Methods; Microbiological synthesis; Molecular weight; nutraceuticals; Polymers; Process controls; Production processes; Retention capacity; Review; Streptococcus; Streptococcus equi - genetics; Streptococcus equi - metabolism; Streptococcus zooepidemicus; Surgery; Toxins; viscoelasticity; Weight control; China

Hyaluronic acid (HA) is a natural and linear polymer composed of repeating disaccharide units of β-1, 3- N -acetyl glucosamine and β-1, 4-glucuronic acid with a molecular weight up to 6 million Daltons. With excellent viscoelasticity, high moisture retention capacity, and high biocompatibility, HA f...