Polymorphisms of genes coding for ghrelin and its receptor in relation to colorectal cancer risk: a two-step gene-wide case-control study

• Published in: BMC gastroenterology Vol. 10; no. 1; p. 112
• Main Authors: Campa, Daniele, Pardini, Barbara, Naccarati, Alessio, Vodickova, Ludmila, Novotny, Jan, Steinke, Verena, Rahner, Nils, Holinski-Feder, Elke, Morak, Monika, Schackert, Hans K, Görgens, Heike, Kötting, Judith, Betz, Beate, Kloor, Matthias, Engel, Christoph, Büttner, Reinhard, Propping, Peter, Försti, Asta, Hemminki, Kari, Barale, Roberto, Vodicka, Pavel, Canzian, Federico
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 28.09.2010; BioMed Central; BMC
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Alleles; Cancer; Child; Clinical Medicine; Colorectal cancer; Colorectal Neoplasms - epidemiology; Colorectal Neoplasms - genetics; Colorectal Neoplasms - metabolism; Czech Republic - epidemiology; DNA, Neoplasm - genetics; Epidemiology; Female; Gastroenterologi; Gastroenterology; Gastroenterology and Hepatology; Genes; Genetic aspects; Genetic polymorphisms; Genetic Predisposition to Disease; Germany - epidemiology; Ghrelin; Ghrelin - genetics; Ghrelin - metabolism; Health aspects; Hormone receptors; Humans; Incidence; Klinisk medicin; Male; Medical and Health Sciences; Medical research; Medicin och hälsovetenskap; Medicine; Middle Aged; Obesity; Polymorphism, Genetic; Receptors, Ghrelin - genetics; Receptors, Ghrelin - metabolism; Retrospective Studies; Risk Factors; Young Adult; Czech Republic; Germany
• ISSN: 1471-230X; 1471-230X
• DOI: 10.1186/1471-230X-10-112

Ghrelin, an endogenous ligand for the growth hormone secretagogue receptor (GHSR), has two major functions: the stimulation of the growth hormone production and the stimulation of food intake. Accumulating evidence also indicates a role of ghrelin in cancer development. We conducted a case-control study to examine the association of common genetic variants in the genes coding for ghrelin (GHRL) and its receptor (GHSR) with colorectal cancer risk. Pairwise tagging was used to select the 11 polymorphisms included in the study. The selected polymorphisms were genotyped in 680 cases and 593 controls from the Czech Republic. We found two SNPs associated with lower risk of colorectal cancer, namely SNPs rs27647 and rs35683. We replicated the two hits, in additional 569 cases and 726 controls from Germany. A joint analysis of the two populations indicated that the T allele of rs27647 SNP exerted a protective borderline effect (Ptrend = 0.004).