Comparative Study of Two Capture Systems for the 24-kD protein of Human Immunodeficiency Virus
A comparative study between HIV-1 Antigen ELISA Test (Coulter, USA) and DAVIH-Ag P24 (DAVIH Laboratories, Cuba) was performed for the detection of HIV-1 P24 antigen. A total of 1039 serum samples of blood donors. sera were studied, in addition to 323 sera from seropositive individuals in different s...
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Published in | Biotecnología aplicada Vol. 17; no. 2; pp. 102 - 104 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | Spanish |
Published |
Cuba
Elfos Scientiae
31.12.2000
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Subjects | |
Online Access | Get full text |
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Summary: | A comparative study between HIV-1 Antigen ELISA Test (Coulter, USA) and
DAVIH-Ag P24 (DAVIH Laboratories, Cuba) was performed for the detection
of HIV-1 P24 antigen. A total of 1039 serum samples of blood donors.
sera were studied, in addition to 323 sera from seropositive
individuals in different stages of the disease. The presence of antigen
was associated with the clinical group and the levels of antibodies
against P24. Both systems showed a high specificity (greater than 99%)
with a concordance of 99.7%. DAVIH-Ag P24 system showed a sensitivity
(58/31) greater than Coulter system when it was tested in the positive
population. Percents of antigenemia were greater in the AIDS group.
Antibody titers against P24 were low or absent in all the sera with
antigenemia to this protein. It was concluded that DAVIH-Ag P24 system
can be used in the follow-up of HIV-1 infected individuals as a
progression marker of the infection, and to screen P24 in blood banks. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 |
ISSN: | 0864-4551 |