Virulence of newcastle disease virus: what is known so far?

• Published in: Veterinary research (Paris) Vol. 42; no. 1; p. 122
• Main Authors: Dortmans, Jos CFM, Koch, Guus, Rottier, Peter JM, Peeters, Ben PH
• Format: Journal Article
• Language: English
• Published: England Springer-Verlag 2011; BioMed Central Ltd; BioMed Central; BMC
• Subjects: Animals; Chickens; cleavage-site; fusion protein; Gene mutations; genes; Genetic aspects; Genetically modified organisms; genetics; hemagglutinin-neuraminidase protein; influenza-a virus; matrix protein; Newcastle disease; Newcastle Disease - virology; Newcastle disease virus; Newcastle disease virus - genetics; Newcastle disease virus - pathogenicity; Newcastle disease virus - physiology; nucleotide-sequence; paramyxovirus-v-proteins; pigeon pmv-1 viruses; Poultry Diseases - virology; Review; strand rna viruses; vesicular stomatitis-virus; Virulence; Virulence Factors - genetics; Netherlands
• ISSN: 1297-9716; 0928-4249; 1297-9716
• DOI: 10.1186/1297-9716-42-122

In the last decade many studies have been performed on the virulence of Newcastle disease virus (NDV). This is mainly due to the development of reverse genetics systems which made it possible to genetically modify NDV and to investigate the contribution of individual genes and genome regions to its virulence. However, the available information is scattered and a comprehensive overview of the factors and conditions determining NDV virulence is lacking. This review summarises, compares and discusses the available literature and shows that virulence of NDV is a complex trait determined by multiple genetic factors.