Exosomes: The Messengers of Health and Disease

Exosomes are small vesicles comprised of a lipid bilayer containing various proteins, RNAs and bioactive lipids. They act as intercellular messengers that give the ability to communicate between both cells of the same type and other cell types. They are released by healthy cells, both constitutively...

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Bibliographic Details
Published inCurrent neuropharmacology Vol. 15; no. 1; pp. 157 - 165
Main Authors Isola, Allison L, Chen, Suzie
Format Journal Article
LanguageEnglish
Published United Arab Emirates Bentham Science Publishers Ltd 01.01.2017
Benham Science Publishers
Bentham Science Publishers
Subjects
Animals
Biological Transport - physiology
Cancer
Cell activation
Cell Communication - physiology
Cellular stress response
Disease Progression
Exosomes
Exosomes - physiology
Humans
Immune system
Lipids
Neoplasms - pathology
Neoplasms - physiopathology
Organelle Biogenesis
Secretory Vesicles
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Summary:Exosomes are small vesicles comprised of a lipid bilayer containing various proteins, RNAs and bioactive lipids. They act as intercellular messengers that give the ability to communicate between both cells of the same type and other cell types. They are released by healthy cells, both constitutively and upon cell activation and play an important role in immune system function. Exosomes are essential for healthy physiological conditions, however under pathological circumstances, they act to potentiate cellular stress and damage. This review explores the characteristics, biogenesis, role(s) in the pathogenesis of diseases and role(s) in progression of cancer of these nano-sized messages-in-a-vesicle: exosomes.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:1570-159X
1875-6190
DOI:10.2174/1570159x14666160825160421