Comparative evaluation of the prophylactic activity of a slow-release insecticide collar and a moxidectin spot-on formulation against Thelazia callipaeda infection in naturally exposed dogs in France

• Published in: Parasites & vectors Vol. 8; no. 1; p. 93
• Main Authors: Lechat, Charlotte, Siméon, Noémie, Pennant, Olivier, Desquilbet, Loïc, Chahory, Sabine, Le Sueur, Christophe, Guillot, Jacques
• Format: Journal Article
• Language: English
• Published: England Springer-Verlag 10.02.2015; BioMed Central Ltd; BioMed Central; BMC
• Subjects: Animal biology; Animals; Care and treatment; Comparative analysis; Disease transmission; Dog; Dog Diseases - parasitology; Dog Diseases - prevention & control; Dogs; Eyeworm; Female; flumethrin; France; fruit flies; Health aspects; health services; imidacloprid; Imidazoles - administration & dosage; Insecticides; Insecticides - administration & dosage; Life Sciences; Macrolides - administration & dosage; Male; Medical research; Medicine, Experimental; moxidectin; Nematoda; Neonicotinoids; Nitro Compounds - administration & dosage; parasites; Prevention; Pyrethrins - administration & dosage; Short Report; Spirurida Infections - parasitology; Spirurida Infections - prevention & control; Spirurida Infections - veterinary; summer; Thelazia; Thelazia callipaeda; Thelazioidea - drug effects; Veterinary medicine and animal Health; France
• ISSN: 1756-3305; 1756-3305
• DOI: 10.1186/s13071-015-0696-6

BACKGROUND: The relative efficacy of a collar containing 10% imidacloprid and 4.5% flumethrin (Seresto®, Bayer HealthCare Animal Health) and a spot on formulation containing 10% imidacloprid and 2.5% moxidectin (Advocate®, Bayer HealthCare Animal Health) was evaluated as a control measure to prevent canine thelaziosis in dogs in an endemic area of France. FINDINGS: Ninety-six privately-owned dogs were enrolled in the multicentre, controlled study. Before summer (the period of transmission by fruit flies), dogs were allocated to one of three groups: Group A (n = 36)- treated once with a collar containing 10% imidacloprid and 4.5% flumethrin; Group B (n = 33)- treated every month for 8 months with a spot-on containing imidacloprid 10% and moxidectin 2.5%; and Group C (n = 27)- untreated control animals. Dogs were regularly subjected to ocular examination in order to assess Thelazia callipaeda infection. During the trial, T. callipaeda nematodes were detected in 12 (33%) collared dogs (group A) whereas no eyeworm could be found in dogs who received a monthly spot on application of moxidectin (group B). In the control group, 8 (30%) dogs became infected. CONCLUSIONS: The monthly application of a spot on formulation containing 10% imidacloprid and 2.5% moxidectin was shown to be highly effective in preventing T. callipaeda infection in a population of dogs living in an endemic area in France. On the contrary, the slow-release collar tested in this study did not display any protection against canine thelaziosis.