Correlation of intestinal microbiota with overweight and obesity in Kazakh school children

• Published in: BMC microbiology Vol. 12; no. 1; p. 283
• Main Authors: Xu, Peiru, Li, Min, Zhang, Jihong, Zhang, Tao
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 28.11.2012; BioMed Central; BMC
• Subjects: Adolescent; Age; Anthropometry; Bacterial Load; Bacteroides; Bacteroidetes - isolation & purification; Blood pressure; Body Mass Index; Case-Control Studies; Child; Children; Children & youth; Comparative analysis; Deoxyribonucleic acid; DNA; Elementary school students; Feces; Female; Firmicutes; Gastrointestinal Tract - microbiology; Gender; Genetic aspects; Gram-Positive Bacteria - isolation & purification; Humans; Influence; Insulin; Insulin resistance; Kazakh; Kazakhstan; Low density lipoprotein; Male; Metabolism; Metagenome; Microbiology; Microbiota (Symbiotic organisms); Obesity; Obesity in children; Obesity, Bacteroidetes; Overweight - microbiology; Pathogenesis; Pediatrics; Physiological aspects; Risk factors; Schools; Students; Studies; Weight gain; Kazakhstan; China
• ISSN: 1471-2180; 1471-2180
• DOI: 10.1186/1471-2180-12-283

This study sought to investigate a possible correlation between the intestinal microbiota, Bacteroidetes and Firmicutes, and obesity in Kazakh school children, aged 7-13 (n = 175). Obese subjects had significantly greater systolic blood pressure, waist and hip circumference, as well as HOMA-IR as compared to normal and overweight participants. In addition, Bacteroides copy number and Bact/Firm ratios were significantly lower in the obese group as compared to the normal and overweight groups (P < 0.0167). This difference is only significant in girls, but not in boys when stratified by gender. Furthermore, a negative correlation between BMI and Bacteroidetes copy number (r = -0.18, P = 0.017) as well as Bact/Firm (r = -0.22, P = 0.003) was observed. An association between reduced gut Bacteroidetes and Bact/Firm ratio with obesity in female Kazakh children was identified. Further studies are necessary to elucidate the mechanism behind these changes as well as the value of determining their presence for predicting obesity.