Targeting the PDGF signaling pathway in tumor treatment

• Published in: Cell communication and signaling Vol. 11; no. 1; p. 97
• Main Author: Heldin, Carl-Henrik
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 20.12.2013; BioMed Central
• Subjects: Angiogenesis Inhibitors - therapeutic use; Animals; Cancer therapies; Cell adhesion & migration; Cell growth; Colorectal cancer; Embryonic development; Health aspects; Humans; Immune system; Kinases; Ligands; Medical prognosis; Molecular weight; Neoplasms - drug therapy; Neoplasms - metabolism; Platelet-derived growth factor; Platelet-Derived Growth Factor - metabolism; Polypeptides; Receptors, Platelet-Derived Growth Factor - metabolism; Review; Rodents; Signal Transduction; Tumors

Platelet-derived growth factor (PDGF) isoforms and PDGF receptors have important functions in the regulation of growth and survival of certain cell types during embryonal development and e.g. tissue repair in the adult. Overactivity of PDGF receptor signaling, by overexpression or mutational events,...