Targeting the PDGF signaling pathway in tumor treatment

Platelet-derived growth factor (PDGF) isoforms and PDGF receptors have important functions in the regulation of growth and survival of certain cell types during embryonal development and e.g. tissue repair in the adult. Overactivity of PDGF receptor signaling, by overexpression or mutational events,...

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Bibliographic Details
Published inCell communication and signaling Vol. 11; no. 1; p. 97
Main Author Heldin, Carl-Henrik
Format Journal Article
LanguageEnglish
Published England BioMed Central Ltd 20.12.2013
BioMed Central
Subjects
Angiogenesis Inhibitors - therapeutic use
Animals
Cancer therapies
Cell adhesion & migration
Cell growth
Colorectal cancer
Embryonic development
Health aspects
Humans
Immune system
Kinases
Ligands
Medical prognosis
Molecular weight
Neoplasms - drug therapy
Neoplasms - metabolism
Platelet-derived growth factor
Platelet-Derived Growth Factor - metabolism
Polypeptides
Receptors, Platelet-Derived Growth Factor - metabolism
Review
Rodents
Signal Transduction
Tumors
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Summary:Platelet-derived growth factor (PDGF) isoforms and PDGF receptors have important functions in the regulation of growth and survival of certain cell types during embryonal development and e.g. tissue repair in the adult. Overactivity of PDGF receptor signaling, by overexpression or mutational events, may drive tumor cell growth. In addition, pericytes of the vasculature and fibroblasts and myofibroblasts of the stroma of solid tumors express PDGF receptors, and PDGF stimulation of such cells promotes tumorigenesis. Inhibition of PDGF receptor signaling has proven to useful for the treatment of patients with certain rare tumors. Whether treatment with PDGF/PDGF receptor antagonists will be beneficial for more common malignancies is the subject for ongoing studies.
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ISSN:1478-811X
1478-811X
DOI:10.1186/1478-811X-11-97