Targeting the PDGF signaling pathway in tumor treatment

Platelet-derived growth factor (PDGF) isoforms and PDGF receptors have important functions in the regulation of growth and survival of certain cell types during embryonal development and e.g. tissue repair in the adult. Overactivity of PDGF receptor signaling, by overexpression or mutational events,...

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Published in	Cell communication and signaling Vol. 11; no. 1; p. 97
Main Author	Heldin, Carl-Henrik
Format	Journal Article
Language	English
Published	England BioMed Central Ltd 20.12.2013 BioMed Central
Subjects	Angiogenesis Inhibitors - therapeutic use Animals Cancer therapies Cell adhesion & migration Cell growth Colorectal cancer Embryonic development Health aspects Humans Immune system Kinases Ligands Medical prognosis Molecular weight Neoplasms - drug therapy Neoplasms - metabolism Platelet-derived growth factor Platelet-Derived Growth Factor - metabolism Polypeptides Receptors, Platelet-Derived Growth Factor - metabolism Review Rodents Signal Transduction Tumors
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Abstract	Platelet-derived growth factor (PDGF) isoforms and PDGF receptors have important functions in the regulation of growth and survival of certain cell types during embryonal development and e.g. tissue repair in the adult. Overactivity of PDGF receptor signaling, by overexpression or mutational events, may drive tumor cell growth. In addition, pericytes of the vasculature and fibroblasts and myofibroblasts of the stroma of solid tumors express PDGF receptors, and PDGF stimulation of such cells promotes tumorigenesis. Inhibition of PDGF receptor signaling has proven to useful for the treatment of patients with certain rare tumors. Whether treatment with PDGF/PDGF receptor antagonists will be beneficial for more common malignancies is the subject for ongoing studies.
AbstractList	Platelet-derived growth factor (PDGF) isoforms and PDGF receptors have important functions in the regulation of growth and survival of certain cell types during embryonal development and e.g. tissue repair in the adult. Overactivity of PDGF receptor signaling, by overexpression or mutational events, may drive tumor cell growth. In addition, pericytes of the vasculature and fibroblasts and myofibroblasts of the stroma of solid tumors express PDGF receptors, and PDGF stimulation of such cells promotes tumorigenesis. Inhibition of PDGF receptor signaling has proven to useful for the treatment of patients with certain rare tumors. Whether treatment with PDGF/PDGF receptor antagonists will be beneficial for more common malignancies is the subject for ongoing studies. Platelet-derived growth factor (PDGF) isoforms and PDGF receptors have important functions in the regulation of growth and survival of certain cell types during embryonal development and e.g. tissue repair in the adult. Overactivity of PDGF receptor signaling, by overexpression or mutational events, may drive tumor cell growth. In addition, pericytes of the vasculature and fibroblasts and myofibroblasts of the stroma of solid tumors express PDGF receptors, and PDGF stimulation of such cells promotes tumorigenesis. Inhibition of PDGF receptor signaling has proven to useful for the treatment of patients with certain rare tumors. Whether treatment with PDGF/PDGF receptor antagonists will be beneficial for more common malignancies is the subject for ongoing studies.Platelet-derived growth factor (PDGF) isoforms and PDGF receptors have important functions in the regulation of growth and survival of certain cell types during embryonal development and e.g. tissue repair in the adult. Overactivity of PDGF receptor signaling, by overexpression or mutational events, may drive tumor cell growth. In addition, pericytes of the vasculature and fibroblasts and myofibroblasts of the stroma of solid tumors express PDGF receptors, and PDGF stimulation of such cells promotes tumorigenesis. Inhibition of PDGF receptor signaling has proven to useful for the treatment of patients with certain rare tumors. Whether treatment with PDGF/PDGF receptor antagonists will be beneficial for more common malignancies is the subject for ongoing studies. Doc number: 97 Abstract: Platelet-derived growth factor (PDGF) isoforms and PDGF receptors have important functions in the regulation of growth and survival of certain cell types during embryonal development and e.g. tissue repair in the adult. Overactivity of PDGF receptor signaling, by overexpression or mutational events, may drive tumor cell growth. In addition, pericytes of the vasculature and fibroblasts and myofibroblasts of the stroma of solid tumors express PDGF receptors, and PDGF stimulation of such cells promotes tumorigenesis. Inhibition of PDGF receptor signaling has proven to useful for the treatment of patients with certain rare tumors. Whether treatment with PDGF/PDGF receptor antagonists will be beneficial for more common malignancies is the subject for ongoing studies. Platelet-derived growth factor (PDGF) isoforms and PDGF receptors have important functions in the regulation of growth and survival of certain cell types during embryonal development and e.g. tissue repair in the adult. Overactivity of PDGF receptor signaling, by overexpression or mutational events, may drive tumor cell growth. In addition, pericytes of the vasculature and fibroblasts and myofibroblasts of the stroma of solid tumors express PDGF receptors, and PDGF stimulation of such cells promotes tumorigenesis. Inhibition of PDGF receptor signaling has proven to useful for the treatment of patients with certain rare tumors. Whether treatment with PDGF/PDGF receptor antagonists will be beneficial for more common malignancies is the subject for ongoing studies.
Audience	Academic
Author	Heldin, Carl-Henrik
AuthorAffiliation	1 Ludwig Institute for Cancer Research, Science for life laboratory, Uppsala University, Box 595SE-751 24 Uppsala, Sweden
AuthorAffiliation_xml	– name: 1 Ludwig Institute for Cancer Research, Science for life laboratory, Uppsala University, Box 595SE-751 24 Uppsala, Sweden
Author_xml	– sequence: 1 givenname: Carl-Henrik surname: Heldin fullname: Heldin, Carl-Henrik
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/24359404$$D View this record in MEDLINE/PubMed https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-215587$$DView record from Swedish Publication Index
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Snippet	Platelet-derived growth factor (PDGF) isoforms and PDGF receptors have important functions in the regulation of growth and survival of certain cell types... Doc number: 97 Abstract: Platelet-derived growth factor (PDGF) isoforms and PDGF receptors have important functions in the regulation of growth and survival of...
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SubjectTerms	Angiogenesis Inhibitors - therapeutic use Animals Cancer therapies Cell adhesion & migration Cell growth Colorectal cancer Embryonic development Health aspects Humans Immune system Kinases Ligands Medical prognosis Molecular weight Neoplasms - drug therapy Neoplasms - metabolism Platelet-derived growth factor Platelet-Derived Growth Factor - metabolism Polypeptides Receptors, Platelet-Derived Growth Factor - metabolism Review Rodents Signal Transduction Tumors
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Title	Targeting the PDGF signaling pathway in tumor treatment
URI	https://www.ncbi.nlm.nih.gov/pubmed/24359404 https://www.proquest.com/docview/1470582032 https://www.proquest.com/docview/1490725674 http://dx.doi.org/10.1186/1478-811X-11-97 https://pubmed.ncbi.nlm.nih.gov/PMC3878225 https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-215587
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