645 Uterine sarcomas in young patients under 40 years of age: an epidemiological national-register-based retrospective cohort study

• Published in: International journal of gynecological cancer Vol. 34; no. Suppl 1; p. A263
• Main Authors: Kostov, Stoyan Georgiev, Kornovski, Yavor Dimitrov, Slavchev, Stanislav Hristov, Ivanova, Yonka Ivanova, Mitkov, Dimitar Metodiev, Watrowski, Rafal, Hasan, Ihsan Hasan, Slaveva, Mariela Vasileva, Yordanov, Angel Danchev
• Format: Journal Article
• Language: English
• Published: Oxford BMJ Publishing Group Ltd 10.03.2024; BMJ Publishing Group LTD
• Subjects: Cohort analysis; Patients; Poster and E-Posters; Sarcoma; Uterine cancer
• ISSN: 1048-891X; 1525-1438
• DOI: 10.1136/ijgc-2024-ESGO.512

Introduction/BackgroundUterine sarcomas (USs) are rare malignant mesenchymal neoplasms, which represent 3–5 % of all malignancies of the uterine corpus. USs rarely affect women under 40 years of age. The study aims to investigate the incidence, clinical stage, and relevant pathological results of young women diagnosed with USs.MethodologyThis is a national-register-based retrospective cohort study of patients with USs (≤ 40 years at diagnosis) registered at Bulgarian National Cancer Registry between 1993 and 2020. Carcinosarcomas were excluded as they represent metaplastic endometrial carcinomas.ResultsPatients of all ages diagnosed with USs during the study period were 569, of which younger women (≤ 40 years at diagnosis) represented 55 patients(9.66%). 38 patients(69%) were diagnosed with uterine leiomyosarcoma(ULMS), 16 patients (29%) with endometrial stromal sarcoma (ESS), and one patient (2%) with undifferentiated uterine sarcoma. The median age of diagnosis of all patients was 35 years and 6 months (the younger patient – 18 years old with ULMS). The median age of diagnosis of ULMS and ESS were 35 years and 3 months, and 35 years and 7 months, respectively. The stage of the disease is known for 26 women with ULMS and 11 women with ESS. Eleven patients (42.3%) with ULMS were diagnosed at stage I of the disease and 10 patients (38.4%), 2 patients (7.6%), 3 patients (11.5%) with stage II, III and IV, respectively. For patients with ESS, 6 women (54.5%), 2 women (18.1%), and 3 women (27.2%) were diagnosed at stage I, II and III, respectively.ConclusionYoung patients with USs represent approximately 10% of patients of all ages diagnosed with uterine sarcoma. ULMS is the most commonly observed histology. Young patients with ULMS are mainly diagnosed at stages I and II of the disease. However, more than 10% of young patients with ULMS are diagnosed at stage IV.DisclosuresThe authors have no relevant financial or non-financial interests to disclose.