764 Preoperative fibrinogen levels as a potential diagnostic marker for uterine sarcomas: a retrospective multivariate analysis

• Published in: International journal of gynecological cancer Vol. 34; no. Suppl 1; pp. A266 - A267
• Main Authors: Kostov, Stoyan, Grigorova, Denitsa, Kornovski, Yavor, Ivanova, Yonka, Slavchev, Stanislav, Hasan, Ihsan, Watrowski, Rafal, Slaveva, Mariela, Mitkov, Dimitar, Yordanov, Angel
• Format: Journal Article
• Language: English
• Published: Oxford BMJ Publishing Group Ltd 10.03.2024; BMJ Publishing Group LTD
• Subjects: Granulocytes; Hemoglobin; Lymphocytes; Poster and E-Posters; Sarcoma
• ISSN: 1048-891X; 1525-1438
• DOI: 10.1136/ijgc-2024-ESGO.520

Introduction/BackgroundUterine sarcomas (USs) are rare mesenchymal malignancies with aggressive behavior and poor prognosis. Preoperative differentiation accuracy of USs and uterine leiomyomas (ULMs) is not satisfactory.MethodologyWe collected observational data on two groups of women. Group I included USs patients with postoperatively confirmed sarcoma on histology and group II included patients with histologically diagnosed uterine leiomyoma. The study included 26 women with USs and 49 women with ULMs. Patients with USs had the following histological subtypes: 16 leiomyosarcomas, 6 endometrial stromal sarcomas, 3 adenosarcomas, and 1 undifferentiated uterine sarcoma. A blood test was performed 24 hours before surgery. Our work aimed to analyze the effects of age, preoperative blood serum levels of leucocytes, platels, hemoglobin, fibrinogen, and granulocytes/lymphocytes ratio on the probability of women being in the USs group. Data were analyzed using R. We applied multiple logistic regression with backward elimination to model the odds ratio (OR) of USs versus ULMs.ResultsWe report the results from the model with predictors of age, hemoglobin, fibrinogen and granulocytes/lymphocytes ratio. The variables hemoglobin and granulocytes/lymphocytes ratio are with p-values close to the boundary of the standard significance level of 5% (6.5% and 6.9% respectively) and we suspect that there is some evidence for their importance in the model. Older with one year women (OR 1.15, 95% CI: (1.06, 1.25), p-value < 0.001) and women with higher levels of the preoperative fibrinogen with one unit (OR 3.71, 95% CI: (1.36, 10.10), p-value = 0.01) were found to have statistically significantly bigger odds of USs.ConclusionBased on the results from the data, the preoperative fibrinogen levels could have a significant role in differentiating patients with USs and ULMs. Further investigation based on data with a bigger sample size is needed to confirm our findings.DisclosuresThe authors have no relevant financial or non-financial interests to disclose.