566 Prognostic importance of pretreatment hematological parameters in locally advanced cervical cancer in a tertiary cancer centre of North East India

• Published in: International journal of gynecological cancer Vol. 34; no. Suppl 1; p. A100
• Main Authors: Barmon, Debabrata, Kumar, Mahendra, Baruah, Upasana, Begum, Dimpy, Bhattacharyya, Moushumee, Roy, Partha Sarathi, Ahmed, Shiraj, Bassetty, Karthik Chandra
• Format: Journal Article
• Language: English
• Published: Oxford BMJ Publishing Group Ltd 10.03.2024; BMJ Publishing Group LTD
• Subjects: Cervical cancer; Hemoglobin; Medical prognosis; Poster and E-Posters; Survival analysis
• ISSN: 1048-891X; 1525-1438
• DOI: 10.1136/ijgc-2024-ESGO.179

Introduction/BackgroundPre-treatment prognostic information is lacking for patients with cervical cancer. Anaemia has long been associated with poor prognosis in patients with cervical cancer. The pre-treatment (Platelet to Lymphocyte ratio) PLR has been demonstrated as significant predictors in patients with cervical cancer. We therefore conducted this study to assess relationship between haematological parameters and survival outcome in cervical cancer.MethodologyIn this study, we retrospectively enrolled patients with locally advanced stage cervical cancer (FIGO stage IIB to IIIC2) who were treated at our centre, from January 2020 to December 2020. Pre-treatment blood parameters were collected and their survival outcome was calculated from hospital records.ResultsTotal 423 patients were registered, out of which 306 (72%) patients were enrolled, in which 276 (90%) patients completed their primary treatment and their progression free survival time (PFS) and overall survival (OS) time was calculated. Pre-treatment haemoglobin level was grouped in 3 categories - <5 gm/dl (3.6%), 5–9 gm/dl (16.3%) and >9 gm/dl (79.3%). Pre-treatment PLR were groups into 3 categories - <90(26%), 90–210 (43.1%) and > 210(29.7%). According to this categorisation, survival analysis was done. Low haemoglobin level was associated with worst PFS & OS (P value – <0.001), whereas optimized pre-treatment haemoglobin was associated with better prognosis. Interesting to note that, normal PLR ratio was associated with best survival PFS & OS, whereas low & high PLR ratio was associated with poor survival outcome (P value - <00.1).ConclusionAbnormal level of haemoglobin and PLR ratio was associated with poor survival outcome in our study. Low PLR was also associated with worst survival outcome, which is a new finding not been reported in existing literature.DisclosuresNone.Abstract 566 Figure 1