EP845 Serous tubal intraepithelial carcinoma in the opportunistic salpingectomy: a case review at mataró hospital

• Published in: International journal of gynecological cancer Vol. 29; no. Suppl 4; p. A462
• Main Authors: Furriols Raulí, B, Rosado Rubio, C, Carabias Meseguer, P, Planas, À Altés, Danés Barris, A, Fantova Cosculluela, MJ
• Format: Journal Article
• Language: English
• Published: Oxford BMJ Publishing Group LTD 01.11.2019
• Subjects: Mutation; Oophorectomy; Ovarian cancer
• ISSN: 1048-891X; 1525-1438
• DOI: 10.1136/ijgc-2019-ESGO.894

Introduction/BackgroundOvarian cancer is the leading cause of gynaecologic cancer death. More than 70% of women are diagnosed with metastatic disease where the 5-year survival rates average 25–30%, and. Efforts have been made in order to achieve a screening approach that reduces mortality in these patients but they have been unsuccessful.In women who carry known pathogenic mutations risk-reducing bilateral salpingo-oophorectomy (rrBSO) is recommended, however they only represent 15–20%, most ovarian cancers (80%) occur in women with no risk factors. The rrBSO has lead to the recognition of a non-invasive precursor lesion, the serous tubal intraepithelial carcinoma (STIC) and it is believed to be the origin of high-grade serous ovarian carcinoma.Incidental STIC lesions in women without a genetic risk factor are rare (0.1%) and for this reason we reviewed this cases in our hospital and described them.MethodologyWe reviewed all the opportunistic salpingectomies from January 2017 to March 2019 in Mataró Hospital and analysed the 3 pure STIC cases.ResultsAmong 254 opportunistic salpingectomies, STIC was found in 3 (1.18%). Patient age ranged from 48 to 72 years (mean 57,6; median 53), one under the age of 50. No patients were known to carry pathogenic mutations. All women were Caucasian and had no familiar or personal history of gynaecologic cancer. Two of them underwent surgery for uterine leyomiomas and the other one for ovarian hypertecosis (BSO). In one case, bilateral oophorectomy was indicated while the other case is being followed annually with ultrasound and CA-125 serum marker.ConclusionThe role of the fallopian tube in ovarian cancer pathogenesis is a subject of interest and it is starting to change clinical practice. It remains uncertain whether opportunistic salpingectomy will reduce ovarian cancer rates. Further research is needed in this area in order to find evidence and create a screening program for ovarian cancer.DisclosureNothing to disclose.