O8 Duplicate FIT testing as a safety netting strategy for patients at risk of colorectal cancer
IntroductionFaecal immunochemical testing (FIT) has been shown to have an acceptable positive predictive value (PPV) and negative predictive value (NPV) for the detection of colorectal cancer (CRC). NHS-E/NICE COVID pandemic guidance recommends that patients with a FIT < 10μgHb/g do not need urge...
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Published in | Gut Vol. 71; no. Suppl 1; p. A5 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
London
BMJ Publishing Group Ltd and British Society of Gastroenterology
19.06.2022
BMJ Publishing Group LTD |
Subjects | |
Online Access | Get full text |
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Summary: | IntroductionFaecal immunochemical testing (FIT) has been shown to have an acceptable positive predictive value (PPV) and negative predictive value (NPV) for the detection of colorectal cancer (CRC). NHS-E/NICE COVID pandemic guidance recommends that patients with a FIT < 10μgHb/g do not need urgent colonic imaging but can be ‘safety-netted’ if not anaemic. Nonetheless concerns remain, that based on a FIT test alone up to 10% of patients with CRC might be missed by this approach, possibly due to the inherent risks of sampling error. The AIM of this study was to determine if the NPV and PPV of FIT could be improved by a strategy of duplicate FIT testing.MethodsAn observational cohort study of duplicate FIT testing of all patients referred on a Lower GI TWW pathway across 4 NHS provider trusts in the Lancashire and South Cumbria Cancer alliance from Jan2019-Feb 2021. FIT samples were analysed at a single centre using OC-sensor with a cut off > 10 μgHb/g of faeces taken as a positive. CRC diagnoses were ascertained from local hospital records and cross referenced with the Somerset Cancer Registry.Results28,622 of 30,105 (95%) referred patients (median [range] age 66y [16–103], 56% female) submitted duplicate FIT tests. 317/28,622 (1.1%) were diagnosed with CRC, of whom 22/317 (59%) were men. Of 18,952/28622 (66%) with two negative FIT tests, CRC was subsequently diagnosed in 7 patients (0.04%) with anaemia (n=7) and right sided tumours (n=6). In contrast, a single FIT strategy would have missed 22 patients of whom only 7 (32%) were anaemic. Interestingly duplicate FIT testing also improved the PPV, which increased from 0.3% if both tests were >10 – 100 μgHb/g to a PPV of 14% if both tests were >100 μgHb/g of faecesConclusionsA strategy of duplicate testing improves the NPV and PPV of FIT and should be considered as a mitigation to reducing missed cancer diagnosis. In patients at risk of CRC with no anaemia, duplicate FIT testing effectively rules out CRC and allows patients to be safely managed in primary care. |
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Bibliography: | Abstracts of the BSG Annual Meeting, 20–23 June 2022 |
ISSN: | 0017-5749 1468-3288 |
DOI: | 10.1136/gutjnl-2022-BSG.8 |