Seroprevalence of Triatoma virus (Dicistroviridae: Cripaviridae) antibodies in Chagas disease patients

• Published in: Parasites & vectors Vol. 8; no. 1; p. 29
• Main Authors: Querido, Jailson FB, Echeverría, María G, Marti, Gerardo A, Costa, Rita Medina, Susevich, María L, Rabinovich, Jorge E, Copa, Aydee, Montaño, Nair A, Garcia, Lineth, Cordova, Marisol, Torrico, Faustino, Sánchez-Eugenia, Rubén, Sánchez-Magraner, Lissete, Muñiz-Trabudua, Xabier, López-Marijuan, Ibai, Rozas-Dennis, Gabriela S, Diosque, Patricio, De Castro, Ana M, Robello, Carlos, Rodríguez, Julio S, Altcheh, Jaime, Salazar-Schettino, Paz M, Bucio, Marta I, Espinoza, Bertha, Guérin, Diego MA, Silva, Marcelo Sousa
• Format: Journal Article
• Language: English
• Published: England Springer-Verlag 17.01.2015; BioMed Central Ltd; BioMed Central; BMC
• Subjects: Americas - epidemiology; Analysis; Animals; Antibodies; Antibodies, Viral - blood; Biological control; blood; Chagas disease; Chagas Disease - blood; Chagas Disease - epidemiology; Chagas Disease - immunology; Dicistroviridae; Dicistroviridae - immunology; Disease transmission; Enzyme-Linked Immunosorbent Assay - methods; feces; hematophagous insects; hosts; Humans; insect vectors; Mathematical model; mathematical models; Models, Biological; parasites; pathogens; patients; people; Pests; Physiological aspects; Portugal - epidemiology; probability; Proteins; Seroepidemiologic Studies; seroprevalence; structural proteins; Triatoma - virology; Triatoma virus; Triatominae; Triatomines; Trypanosoma cruzi; Viral antibodies; Viral Structural Proteins - immunology; viruses; Bolivia; Mexico; Argentina; Americas; Portugal; Spain
• ISSN: 1756-3305; 1756-3305
• DOI: 10.1186/s13071-015-0632-9

BACKGROUND: Chagas disease is caused by Trypanosoma cruzi, and humans acquire the parasite by exposure to contaminated feces from hematophagous insect vectors known as triatomines. Triatoma virus (TrV) is the sole viral pathogen of triatomines, and is transmitted among insects through the fecal-oral route and, as it happens with T. cruzi, the infected insects release the virus when defecating during or after blood uptake. METHODS: In this work, we analysed the occurrence of anti-TrV antibodies in human sera from Chagas disease endemic and non-endemic countries, and developed a mathematical model to estimate the transmission probability of TrV from insects to man, which ranged between 0.00053 and 0.0015. RESULTS: Our results confirm that people with Chagas disease living in Bolivia, Argentina and Mexico have been exposed to TrV, and that TrV is unable to replicate in human hosts. CONCLUSIONS: We presented the first experimental evidence of antibodies against TrV structural proteins in human sera.