Effects of the lactase 13910 C/T and calcium-sensor receptor A986S G/T gene polymorphisms on the incidence and recurrence of colorectal cancer in Hungarian population

• Published in: BMC cancer Vol. 8; no. 1; p. 317
• Main Authors: Bácsi, Krisztián, Hitre, Erika, Kósa, János P, Horváth, Henrik, Lazáry, Aron, Lakatos, Péter L, Balla, Bernadett, Budai, Barna, Lakatos, Péter, Speer, Gábor
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 03.11.2008; BioMed Central; BMC
• Subjects: Calcium metabolism; Colorectal cancer; Colorectal Neoplasms - blood; Colorectal Neoplasms - epidemiology; Colorectal Neoplasms - genetics; Disease Progression; Female; Genetic aspects; Genetic polymorphisms; Health aspects; Humans; Hungary - epidemiology; Incidence; Lactase - genetics; Male; Middle Aged; Neoplasm Recurrence, Local - genetics; Odds Ratio; Polymorphism, Genetic; Receptors, Calcium-Sensing - genetics; Risk factors; Hungary
• ISSN: 1471-2407; 1471-2407
• DOI: 10.1186/1471-2407-8-317

Epidemiological studies suggested the chemopreventive role of higher calcium intake in colorectal carcinogenesis. We examined genetic polymorphisms that might influence calcium metabolism: lactase (LCT) gene 13910 C/T polymorphism causing lactose intolerance and calcium-sensing receptor (CaSR) gene A986S polymorphism as a responsible factor for the altered cellular calcium sensation. 538 Hungarian subjects were studied: 278 patients with colorectal cancer and 260 healthy controls. Median follow-up was 17 months. After genotyping, the relationship between LCT 13910 C/T and CaSR A986S polymorphisms as well as tumor incidence/progression was investigated. in patient with colorectal cancer, a significantly higher LCT CC frequency was associated with increased distant disease recurrence (OR = 4.04; 95% CI = 1.71-9.58; p = 0.006). The disease free survival calculated from distant recurrence was reduced for those with LCT CC genotype (log rank test p = 0.008). In case of CaSR A986S polymorphism, the homozygous SS genotype was more frequent in patients than in controls (OR = 4.01; 95% CI = 1.33-12.07; p = 0.014). The number of LCT C and CaSR S risk alleles were correlated with tumor incidence (p = 0.035). The CCSS genotype combination was found only in patients with CRC (p = 0.033). LCT 13910 C/T and CaSR A986S polymorphisms may have an impact on the progression and/or incidence of CRC.