Animal models of diabetic retinopathy: doors to investigate pathogenesis and potential therapeutics

• Published in: Journal of biomedical science Vol. 20; no. 1; p. 38
• Main Authors: Jo, Dong Hyun, Cho, Chang Sik, Kim, Jin Hyoung, Jun, Hyoung Oh, Kim, Jeong Hun
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 20.06.2013; BioMed Central
• Subjects: Analysis; Animals; Danio rerio; Diabetic retinopathy; Diabetic Retinopathy - pathology; Diabetic Retinopathy - therapy; Disease Models, Animal; Hemorrhage; Homeopathy; Humans; Laboratory animals; Materia medica and therapeutics; Medical research; Pathogenesis; Retina; Review; Rodents; Studies; Therapeutics; Vascular endothelial growth factor
• ISSN: 1423-0127; 1021-7770; 1423-0127
• DOI: 10.1186/1423-0127-20-38

Effective and validated animal models are valuable to investigate the pathogenesis and potential therapeutics for human diseases. There is much concern for diabetic retinopathy (DR) in that it affects substantial number of working population all around the world, resulting in visual deterioration and social deprivation. In this review, we discuss animal models of DR based on different species of animals from zebrafish to monkeys and prerequisites for animal models. Despite criticisms on imprudent use of laboratory animals, we hope that animal models of DR will be appropriately utilized to deepen our understanding on the pathogenesis of DR and to support our struggle to find novel therapeutics against catastrophic visual loss from DR.