Mass spectrometry-based analysis of glycoproteins and its clinical applications in cancer biomarker discovery

Glycosylation is one of the most important posttranslational modifications of proteins and plays essential roles in various biological processes. Aberration in the glycan moieties of glycoproteins is associated with many diseases. It is especially critical to develop the rapid and sensitive methods...

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Published inClinical proteomics Vol. 11; no. 1; p. 14
Main Authors Liu, Huan, Zhang, Ningbo, Wan, Debin, Cui, Meng, Liu, Zhiqiang, Liu, Shuying
Format Journal Article
LanguageEnglish
Published England BioMed Central Ltd 10.04.2014
BioMed Central
Springer
Subjects
Binding sites
Biomarkers
Cancer
Carbohydrates
Chromatography
Data analysis
Glycoproteins
Ions
Mass spectrometry
Methods
Peptides
Polysaccharides
Proteins
Review
Technological change
Technology application
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Summary:Glycosylation is one of the most important posttranslational modifications of proteins and plays essential roles in various biological processes. Aberration in the glycan moieties of glycoproteins is associated with many diseases. It is especially critical to develop the rapid and sensitive methods for analysis of aberrant glycoproteins associated with diseases. Mass spectrometry (MS) has become a powerful tool for glycoprotein analysis. Especially, tandem mass spectrometry can provide highly informative fragments for structural identification of glycoproteins. This review provides an overview of the development of MS technologies and their applications in identification of abnormal glycoproteins and glycans in human serum to screen cancer biomarkers in recent years.
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ISSN:1542-6416
1559-0275
1559-0275
DOI:10.1186/1559-0275-11-14