Genetic determinants of bone mineral content in premature infants

• Published in: Archives of disease in childhood. Fetal and neonatal edition Vol. 85; no. 3; pp. F214 - F216
• Main Authors: Backström, M C, Mahonen, A, Ala-Houhala, M, Sievänen, H, Mäenpää, P, Koivisto, A M, Olkku, A, Mäki, R, Mäki, M
• Format: Journal Article
• Language: English
• Published: London BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health 01.11.2001; BMJ; BMJ Publishing Group Ltd; BMJ Publishing Group LTD; National Library of Medicine - MEDLINE Abstracts; BMJ Group
• Subjects: Absorptiometry, Photon - methods; Age; Alleles; Analysis; Analysis of Variance; Binding sites; Biological and medical sciences; Birth weight; Body Weight; Bone Density - genetics; bone mineral status; Bones; Child; collagen; Density; Deoxyribonucleic acid; Diseases of the osteoarticular system; DNA; Electrophoresis, Agar Gel - methods; Genes; Genetic research; Genotype; Genotype & phenotype; Health aspects; Humans; Infant; Infant, Newborn; Infant, Premature - physiology; Infants (Premature); Insulin-like growth factor 1; insulin-like growth factor I; Insulin-Like Growth Factor I - genetics; Insulin-like growth factors; Medical sciences; Miscellaneous. Osteoarticular involvement in other diseases; oestrogen; Original; Physiological aspects; Polymerase Chain Reaction - methods; Polymorphism, Restriction Fragment Length; Receptors, Calcitriol - genetics; Receptors, Estrogen - genetics; vitamin D receptor; United Kingdom; Human; Pregnancy disorders; Estrogen; Genotype; Infant; Insulin like growth factor 1; Genetic determinism; Newborn diseases; Collagen type I; Prematurity; Vitamin D; Molecular epidemiology; Bone mineral density; Child; Antecedent; Biological receptor
• ISSN: 1359-2998; 1468-2052
• DOI: 10.1136/fn.85.3.F214

Genetic determinants of bone mineral content in prematurely born children at 3 months and 9–11 years of age were studied. The findings suggest that multiple genes are involved in the regulation of site specific bone mass accumulation during childhood.