Functional site prediction selects correct protein models

• Published in: BMC bioinformatics Vol. 9; no. S1; p. S13
• Main Authors: Chelliah, Vijayalakshmi, Taylor, William R
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 13.02.2008; BioMed Central; BMC
• Subjects: Algorithms; Amino Acid Sequence; Binding Sites; Computer Simulation; Models, Chemical; Models, Molecular; Molecular Sequence Data; Proceedings; Protein Binding; Proteins - chemistry; Proteins - ultrastructure; Sequence Analysis, Protein - methods; Structure-Activity Relationship

The prediction of protein structure can be facilitated by the use of constraints based on a knowledge of functional sites. Without this information it is still possible to predict which residues are likely to be part of a functional site and this information can be used to select model structures fr...