Response of bone metabolism related hormones to a single session of strenuous exercise in active elderly subjects

• Published in: British journal of sports medicine Vol. 39; no. 8; pp. 497 - 502
• Main Authors: Maïmoun, L, Simar, D, Malatesta, D, Caillaud, C, Peruchon, E, Couret, I, Rossi, M, Mariano-Goulart, D
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group Ltd and British Association of Sport and Exercise Medicine 01.08.2005; BMJ Publishing Group LTD; BMJ Publishing Group; BMJ Group
• Subjects: 1.25(OH); 1.25(OH)2D3; 1.25-dihydroxy-vitamin D3; 25(OH)D; 25(OH)D, 25-hydroxyvitamin D; 25-hydroxyvitamin D; Age; Aged; Aged, 80 and over; Alcohol; B-ALP; B-ALP, bone alkaline phosphatase; beats per minute; Biomarkers - blood; BMD; BMD, bone mineral density; BMI; BMI, body mass index; Body Mass Index; bone alkaline phosphatase; Bone and Bones - metabolism; bone biochemical markers; Bone density; bone mineral density; Bone Resorption - metabolism; bone turnover; Bones; bpm; bpm, beats per minute; Calcium; Calcium - blood; CO; CO2 output; coefficient of variation; CTX; CTX, type I collagen C-telopeptide; CV, coefficient of variation; D3, 1.25-dihydroxy-vitamin D3; Enzyme-Linked Immunosorbent Assay - methods; Exercise; Family medical history; Female; Fractures; haematocrit; haemoglobin; Hb, haemoglobin; Hct; Hct, haematocrit; heart rate; Homeostasis; Homeostasis - physiology; Hormones; Hormones - blood; HR, heart rate; Humans; Hydroxycholecalciferols - blood; iCa; iCa, ionised calcium; immunoradiometric assay; intact parathyroid hormone; ionised calcium; iPTH; iPTH, intact parathyroid hormone; IRMA; IRMA, immunoradiometric assay; Male; Medical research; Metabolic disorders; Metabolism; Middle Aged; Mortality; OC, osteocalcin; Older people; Original; Original articles; osteocalcin; Osteocalcin - analysis; Osteogenesis - physiology; Osteoporosis; output; oxygen consumption; Oxygen Consumption - physiology; Parathyroid Hormone - blood; physical activity; Physical fitness; radioimmunoassay; RER; RER, respiratory exchange ratio; respiratory exchange ratio; RIA; RIA, radioimmunoassay; Studies; type I collagen C-telopeptide; Vco; Vco2; VE, ventilation; ventilation; Vo2; Walking; Walking - physiology; France
• ISSN: 0306-3674; 1473-0480; 1473-0480
• DOI: 10.1136/bjsm.2004.013151

Objective: To evaluate the effect of strenuous exercise on bone metabolism and related hormones in elderly subjects. Methods: Twenty one active elderly subjects (11 men and 10 women; mean age 73.3 years) showing a mean theoretical Vo2max of 151.4% participated. Concentrations of plasma ionised calcium (iCa), serum intact parathyroid hormone (iPTH), 25-hydroxyvitamin D (25(OH)D), and 1.25-dihydroxy-vitamin D3 (1.25(OH)2D3), as well as the bone biochemical markers type I collagen C-telopeptide for bone resorption and osteocalcin and bone alkaline phosphatase for bone formation, were analysed before and after a maximal incremental exercise test. Results: At basal level, iPTH was positively correlated with age (r = 0.56, p<0.01) and negatively correlated with 25(OH)D (r = −0.50; p<0.01) and 1.25(OH)2D3 (r = −0.47; p<0.05). Moreover, 25(OH)D and 1.25(OH)2D3 levels were negatively correlated with age (r = −0.50, p<0.01 and r = −0.53, p<0.01, respectively). After exercise, iCa and 25(OH)D decreased (p<0.001 and p = 0.01, respectively) while iPTH increased (p<0.001). The levels of 1.25(OH)2D3, bone biochemical markers, haematocrit, and haemoglobin were unchanged. The variations in iCa and 25(OH)D were not related to age and/or sex. The iPTH variation was directly related to basal iPTH levels (p<0.01) and indirectly related to age. Conclusions: In active elderly subjects, strenuous exercise disturbed calcium homeostasis and bone related hormones without immediate measurable effect on bone turnover. Although an increase in iPTH could have an anabolic action on bone tissue, our findings from our short term study did not allow us to conclude that such action occurred.