Preterm infant circulating sex steroid levels are not altered by transfusion with adult male plasma: a retrospective multicentre cohort study

• Published in: Archives of disease in childhood. Fetal and neonatal edition Vol. 107; no. 6; pp. 577 - 582
• Main Authors: Nilsson, Anders K, Hellgren, Gunnel, Sjöbom, Ulrika, Landin, Andreas, Ryberg, Henrik, Wackernagel, Dirk, Ley, David, Hansen Pupp, Ingrid, Poutanen, Matti, Ohlsson, Claes, Hellstrom, Ann
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health 01.11.2022; BMJ Publishing Group LTD; BMJ Publishing Group
• Subjects: androgen; Androgens; blood; born; brain; Children & youth; Clinical Medicine; Cohort analysis; cortex; endocrinology; establishment; estradiol; Females; Gender; hormone-binding globulin; Hormones; Hospitals; Infants; intensive care units; intensive care units, neonatal; Klinisk medicin; Males; Medical and Health Sciences; Medicin och hälsovetenskap; neonatal; neonatology; Neurosciences; Newborn babies; Original Research; Pediatrics; Pediatrik; pituitary-gland; Plasma; Premature babies; Steroids; Testosterone; Transfusion; Sweden; intensive care units, neonatal; neonatology; endocrinology
• ISSN: 1359-2998; 1468-2052; 1468-2052
• DOI: 10.1136/archdischild-2021-323433

ObjectiveTo determine if plasma transfusions with male donor plasma to very preterm infants affect circulatory levels of sex steroids.Design and patientsRetrospective multicentre cohort study in 19 infants born at gestational age <29 weeks requiring plasma transfusion during their first week of life.SettingThree neonatal intensive care units in Sweden.Main outcome measuresConcentrations of sex steroids and sex hormone-binding globulin (SHBG) in donor plasma and infant plasma measured before and after a plasma transfusion and at 6, 12, 24 and 72 hours.ResultsThe concentrations of progesterone, dehydroepiandrosterone and androstenedione were significantly lower in donor plasma than in infant plasma before the transfusion (median (Q1–Q3) 37.0 (37.0–37.0), 1918 (1325–2408) and 424 (303–534) vs 901 (599–1774), 4119 (2801–14 645) and 842 (443–1684) pg/mL), while oestrone and oestradiol were higher in donor plasma (17.4 (10.4–20.1) and 16.0 (11.7–17.2) vs 3.1 (1.1–10.2) and 0.25 (0.25–0.25) pg/mL). Median testosterone and dihydrotestosterone (DHT) levels were 116-fold and 21-fold higher in donor plasma than pre-transfusion levels in female infants, whereas the corresponding difference was not present in male infants. Plasma sex steroid levels were unchanged after completed transfusion compared with pre-transfusion levels, irrespective of the gender of the receiving infant. The SHBG concentration was significantly higher in donor than in recipient plasma (22.8 (17.1–33.5) vs 10.2 (9.1–12.3) nmol/L) before transfusion but did not change in the infants after the transfusion.ConclusionsA single transfusion of adult male plasma to preterm infants had no impact on circulating sex steroid levels.