Identification and monitoring of brain activity based on stochastic relevance analysis of short-time EEG rhythms

• Published in: Biomedical engineering online Vol. 13; no. 1; p. 123
• Main Authors: Duque-Muñoz, Leonardo, Espinosa-Oviedo, Jairo Jose, Castellanos-Dominguez, Cesar German
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 28.08.2014; BioMed Central
• Subjects: Accuracy; Analysis; Automation; Brain - diagnostic imaging; Care and treatment; Classification; Decomposition; Diagnosis; Electroencephalography; Electroencephalography - methods; Epilepsy; Epilepsy - diagnosis; Epilepsy - therapy; Fourier transforms; Humans; Medical research; Medicine, Experimental; Methods; Models, Theoretical; Monitoring, Physiologic - methods; Nervous System Physiological Phenomena; Neurons; Physiological aspects; Principal components analysis; Radiography; Rhythm; Seizures - diagnosis; Seizures - therapy; Signal processing; Support Vector Machine; Wavelet transforms
• ISSN: 1475-925X; 1475-925X
• DOI: 10.1186/1475-925X-13-123

The extraction of physiological rhythms from electroencephalography (EEG) data and their automated analyses are extensively studied in clinical monitoring, to find traces of interictal/ictal states of epilepsy. Because brain wave rhythms in normal and interictal/ictal events, differently influence neuronal activity, our proposed methodology measures the contribution of each rhythm. These contributions are measured in terms of their stochastic variability and are extracted from a Short Time Fourier Transform to highlight the non-stationary behavior of the EEG data. Then, we performed a variability-based relevance analysis by handling the multivariate short-time rhythm representation within a subspace framework. This maximizes the usability of the input information and preserves only the data that contribute to the brain activity classification. For neural activity monitoring, we also developed a new relevance rhythm diagram that qualitatively evaluates the rhythm variability throughout long time periods in order to distinguish events with different neuronal activities. Evaluations were carried out over two EEG datasets, one of which was recorded in a noise-filled environment. The method was evaluated for three different classification problems, each of which addressed a different interpretation of a medical problem. We perform a blinded study of 40 patients using the support-vector machine classifier cross-validation scheme. The obtained results show that the developed relevance analysis was capable of accurately differentiating normal, ictal and interictal activities. The proposed approach provides the reliable identification of traces of interictal/ictal states of epilepsy. The introduced relevance rhythm diagrams of physiological rhythms provides effective means of monitoring epileptic seizures; additionally, these diagrams are easily implemented and provide simple clinical interpretation. The developed variability-based relevance analysis can be translated to other monitoring applications involving time-variant biomedical data.