Molecular profiling of T-helper immune genes during dengue virus infection

• Published in: Virology journal Vol. 5; no. 1; p. 165
• Main Authors: Chen, Jincheng, Ng, Mary Mah Lee, Chu, Justin Jang Hann
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 31.12.2008; BioMed Central; BMC
• Subjects: Antigens, CD - genetics; Antigens, Differentiation, T-Lymphocyte - genetics; Biomarkers; CD4 lymphocytes; Cell Line, Tumor; Chemokine CCL5 - genetics; Dengue - genetics; Dengue - immunology; Dengue viruses; Gene Expression Profiling; Genetic aspects; Hepatocytes - metabolism; Hepatocytes - virology; Humans; Immune response; Interferon Regulatory Factors - genetics; Interleukin-6 - genetics; Lectins, C-Type; Lymphocyte Activation - genetics; Monocytes - metabolism; Monocytes - virology; Physiological aspects; Receptors, CCR3 - genetics; Short Report; T-Lymphocytes, Helper-Inducer - immunology; Toll-Like Receptor 6 - genetics; Up-Regulation; Singapore

In this study, we provide a comprehensive molecular profiling of the involvement of T- helper (Th) genes during dengue virus infection of different cell types. The Th gene profiles of three human cell types (monocytes, T-cells and hepatocytes) were analyzed simultaneously via array-based RT-PCR upon...