Neuroregeneration in Parkinson's Disease: From Proteins to Small Molecules

• Published in: Current neuropharmacology Vol. 17; no. 3; pp. 268 - 287
• Main Authors: SIDOROVA, Yulia A., VOLCHO, Konstantin P., SALAKHUTDINOV, Nariman F.
• Format: Journal Article
• Language: English
• Published: United Arab Emirates Bentham Science Publishers Ltd 01.01.2019; Bentham Science Publishers; Benham Science Publishers
• Subjects: Animal models; Animals; BDNF; BDNF mimetics; Databases, Bibliographic; Dopamine; dopamine neurons; Drug development; GDNF; GDNF mimetics; Humans; Molecular Weight; Movement disorders; Nerve Regeneration - drug effects; Neurodegeneration; Neurodegenerative diseases; Neurons; neuroprotection; Neurorestoration; Neurotrophic factors; Parkinson Disease - drug therapy; Parkinson Disease - metabolism; Parkinson's disease; Proteins - therapeutic use; RET agonists; Trk agonists; BDNF mimetics; RET agonists; dopamine neurons; Neurorestoration; Parkinson's disease; GDNF; BDNF; neuroprotection; neurotrophic factors; GDNF mimetics; Trk agonists

Background: Parkinson’s disease (PD) is the second most common neurodegenerative disorder worldwide, the lifetime risk of developing this disease is 1.5%. Motor diagnostic symptoms of PD are caused by degeneration of nigrostriatal dopamine neurons. There is no cure for PD and current therapy is limi...