Collision tumour involving a rectal gastrointestinal stromal tumour with invasion of the prostate and a prostatic adenocarcinoma

• Published in: Diagnostic pathology Vol. 7; no. 1; p. 150
• Main Authors: Macías-García, Laura, De la Hoz-Herazo, Haydee, Robles-Frías, Antonio, Pareja-Megía, María J, López-Garrido, Juan, López, José I
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 30.10.2012; BioMed Central; BMC
• Subjects: Adenocarcinoma; Adenocarcinoma - chemistry; Adenocarcinoma - pathology; Adenocarcinoma - therapy; Antineoplastic Agents - therapeutic use; Benzamides - therapeutic use; Biomarkers, Tumor - analysis; Biopsy; Chemotherapy, Adjuvant; Diagnosis, Differential; Gastrointestinal Stromal Tumors - chemistry; Gastrointestinal Stromal Tumors - pathology; Gastrointestinal Stromal Tumors - therapy; Gastrointestinal stromal tumour; Gastrointestinal system; Humans; Imatinib; Imatinib Mesylate; Immunohistochemistry; Magnetic Resonance Imaging; Male; Middle Aged; Mixed tumours; Neoadjuvant Therapy; Neoplasm Invasiveness; Neoplasms, Multiple Primary - chemistry; Neoplasms, Multiple Primary - pathology; Neoplasms, Multiple Primary - therapy; Piperazines - therapeutic use; Predictive Value of Tests; Prostate - chemistry; Prostate - pathology; Prostate - surgery; Prostate cancer; Prostatectomy; Prostatic adenocarcinoma; Prostatic Neoplasms - chemistry; Prostatic Neoplasms - pathology; Prostatic Neoplasms - therapy; Pyrimidines - therapeutic use; Rectal Neoplasms - chemistry; Rectal Neoplasms - pathology; Rectal Neoplasms - therapy; Short Report; Stem cells; Tomography, X-Ray Computed; Treatment Outcome; Tumors
• ISSN: 1746-1596; 1746-1596
• DOI: 10.1186/1746-1596-7-150

Gastrointestinal stromal tumours (GISTs) are the most common primary mesenchymal neoplasia in the gastrointestinal tract, although they represent only a small fraction of total gastrointestinal malignancies in adults (<2%). GISTs can be located at any level of the gastrointestinal tract; the stomach is the most common location (60-70%), in contrast to the rectum, which is most rare (4%). When a GIST invades into the adjacent prostate tissue, it can simulate prostate cancer. In this study, we report on a case comprising the unexpected collision between a rectal GIST tumour and a prostatic adenocarcinoma. We describe the complexity of the clinical, endoscopic and radiological diagnosis, of the differential diagnosis based on tumour biopsy, and of the role of neoadjuvant therapy using imatinib prior to surgical treatment. Although isolated cases of coexisting GISTs and prostatic adenocarcinomas have previously been described, this is the first reported case in the medical literature of a collision tumour involving a rectal GIST and prostatic adenocarcinoma components. The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1238437468776331.