Pancreatic cancer risk and levels of trace elements

• Published in: Gut Vol. 61; no. 11; pp. 1583 - 1588
• Main Authors: Amaral, André F S, Porta, Miquel, Silverman, Debra T, Milne, Roger L, Kogevinas, Manolis, Rothman, Nathaniel, Cantor, Kenneth P, Jackson, Brian P, Pumarega, José A, López, Tomàs, Carrato, Alfredo, Guarner, Luisa, Real, Francisco X, Malats, Núria
• Format: Journal Article
• Language: English
• Published: London BMJ Publishing Group Ltd and British Society of Gastroenterology 01.11.2012; BMJ Publishing Group; BMJ Publishing Group LTD
• Subjects: Adult; Age Distribution; Aged; Arsenic; Arsenic - analysis; Biological and medical sciences; Biomarkers, Tumor - analysis; Bladder cancer; Cadmium; Cadmium - analysis; cancer; Case-Control Studies; Confidence Intervals; Diabetes; epidemiology; epithelial differentiation; Family medical history; Female; Fingers & toes; Gastroenterology. Liver. Pancreas. Abdomen; genetics; Health risk assessment; Humans; Incidence; Lead; Lead - analysis; Lead content; Liver. Biliary tract. Portal circulation. Exocrine pancreas; Logistic Models; Male; Medical sciences; Middle Aged; molecular carcinogenesis; molecular epidemiology; molecular oncology; mucins; Nails - chemistry; Nickel - analysis; Odds Ratio; Pancreas; Pancreas, Exocrine - metabolism; Pancreas, Exocrine - pathology; Pancreatic cancer; pancreatic epidemiology; Pancreatic Neoplasms - diagnosis; Pancreatic Neoplasms - epidemiology; Pancreatic Neoplasms - metabolism; pancreatic tumours; Pathogenesis; polymorphic variation; Prognosis; Quality control; Retrospective Studies; Risk Assessment; Selenium; Selenium - analysis; Sex Distribution; Smoking; Spain - epidemiology; statistics; Studies; Testing laboratories; Tobacco; Trace Elements - analysis; Tumors; Water pollution; Spain; Trace element; Pancreas cancer; Risk factor; Gastroenterology; Digestive diseases; Malignant tumor; Cancer; Pancreatic disease

Background and Aims Knowledge on the aetiology of exocrine pancreatic cancer (EPC) is scant. The best established risk factor for EPC is tobacco smoking. Among other carcinogens, tobacco contains cadmium, a metal previously associated with an increased risk of EPC. This study evaluated the associati...