Genetic predisposition to fracture non-union: a case control study of a preliminary single nucleotide polymorphisms analysis of the BMP pathway

• Published in: BMC musculoskeletal disorders Vol. 12; no. 1; p. 44
• Main Authors: Dimitriou, Rozalia, Carr, Ian M, West, Robert M, Markham, Alexander F, Giannoudis, Peter V
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 10.02.2011; BioMed Central; BMC
• Subjects: Adult; Aged; Analysis; Bone Morphogenetic Protein 2 - genetics; Bone Morphogenetic Protein 7 - genetics; Bone Morphogenetic Proteins - genetics; Carrier Proteins - genetics; Case-Control Studies; Cellular signal transduction; Disease; Disease susceptibility; Female; Fracture fixation; Fractures, Ununited; Fractures, Ununited - epidemiology; Fractures, Ununited - genetics; Gene therapy; Genetic aspects; Genetic Predisposition to Disease - genetics; Genetic testing; Genetics; Genotype; Humans; Male; Middle Aged; Physiological aspects; Pilot Projects; Polymorphism, Single Nucleotide - genetics; Risk Factors; Signal transduction; Signal Transduction - genetics; Single nucleotide polymorphisms; Smad6 Protein - genetics; Studies; Teaching hospitals; Tissue engineering

Despite the known multi-factorial nature of atrophic fracture non-unions, a possible genetic predisposition for the development of this complication after long bone fractures remains unknown. This pilot study aimed to address this issue by performing a preliminary SNP analysis of specific genes know...