Chemical fingerprinting and quantitative analysis of a Panax notoginseng preparation using HPLC-UV and HPLC-MS

Xuesaitong (XST) injection, consisting of total saponins from Panax notoginseng, was widely used for the treatment of cardio- and cerebro-vascular diseases in China. This study develops a simple and global quality evaluation method for the quality control of XST. High performance liquid chromatograp...

Full description

Saved in:
Bibliographic Details
Published inChinese medicine Vol. 6; no. 1; p. 9
Main Authors Yao, Hong, Shi, Peiying, Shao, Qing, Fan, Xiaohui
Format Journal Article
LanguageEnglish
Published England BioMed Central Ltd 24.02.2011
BioMed Central
BMC
Subjects
Analytical chemistry
Chromatography
Health aspects
High performance liquid chromatography
Mass spectrometry
Saponins
Spectrum analysis
China
Online AccessGet full text

Cover

Abstract Xuesaitong (XST) injection, consisting of total saponins from Panax notoginseng, was widely used for the treatment of cardio- and cerebro-vascular diseases in China. This study develops a simple and global quality evaluation method for the quality control of XST. High performance liquid chromatography-ultraviolet detection (HPLC-UV) was used to identify and quantify the chromatographic fingerprints of the XST injection. Characteristic common peaks were identified using HPLC with photo diode array detection/electrospray ionization tandem mass spectrometry (HPLC-PDA/ESI-MSn). Representative fingerprints from ten batches of samples showed 27 'common saponins' all of which were identified and quantified using ten reference saponins. Chemical fingerprinting and quantitative analysis identified most of the common saponins for the quality control of P. notoginseng products such as the XST injection.
AbstractList Abstract Background Xuesaitong (XST) injection, consisting of total saponins from Panax notoginseng , was widely used for the treatment of cardio- and cerebro-vascular diseases in China. This study develops a simple and global quality evaluation method for the quality control of XST. Methods High performance liquid chromatography-ultraviolet detection (HPLC-UV) was used to identify and quantify the chromatographic fingerprints of the XST injection. Characteristic common peaks were identified using HPLC with photo diode array detection/electrospray ionization tandem mass spectrometry (HPLC-PDA/ESI-MS n ). Results Representative fingerprints from ten batches of samples showed 27 'common saponins' all of which were identified and quantified using ten reference saponins. Conclusion Chemical fingerprinting and quantitative analysis identified most of the common saponins for the quality control of P. notoginseng products such as the XST injection.
Abstract Background Xuesaitong (XST) injection, consisting of total saponins from Panax notoginseng, was widely used for the treatment of cardio- and cerebro-vascular diseases in China. This study develops a simple and global quality evaluation method for the quality control of XST. Methods High performance liquid chromatography-ultraviolet detection (HPLC-UV) was used to identify and quantify the chromatographic fingerprints of the XST injection. Characteristic common peaks were identified using HPLC with photo diode array detection/electrospray ionization tandem mass spectrometry (HPLC-PDA/ESI-MSn). Results Representative fingerprints from ten batches of samples showed 27 'common saponins' all of which were identified and quantified using ten reference saponins. Conclusion Chemical fingerprinting and quantitative analysis identified most of the common saponins for the quality control of P. notoginseng products such as the XST injection.
BACKGROUNDXuesaitong (XST) injection, consisting of total saponins from Panax notoginseng, was widely used for the treatment of cardio- and cerebro-vascular diseases in China. This study develops a simple and global quality evaluation method for the quality control of XST. METHODSHigh performance liquid chromatography-ultraviolet detection (HPLC-UV) was used to identify and quantify the chromatographic fingerprints of the XST injection. Characteristic common peaks were identified using HPLC with photo diode array detection/electrospray ionization tandem mass spectrometry (HPLC-PDA/ESI-MSn). RESULTSRepresentative fingerprints from ten batches of samples showed 27 'common saponins' all of which were identified and quantified using ten reference saponins. CONCLUSIONChemical fingerprinting and quantitative analysis identified most of the common saponins for the quality control of P. notoginseng products such as the XST injection.
BACKGROUND: Xuesaitong (XST) injection, consisting of total saponins from Panax notoginseng, was widely used for the treatment of cardio- and cerebro-vascular diseases in China. This study develops a simple and global quality evaluation method for the quality control of XST. METHODS: High performance liquid chromatography-ultraviolet detection (HPLC-UV) was used to identify and quantify the chromatographic fingerprints of the XST injection. Characteristic common peaks were identified using HPLC with photo diode array detection/electrospray ionization tandem mass spectrometry (HPLC-PDA/ESI-MSn). RESULTS: Representative fingerprints from ten batches of samples showed 27 'common saponins' all of which were identified and quantified using ten reference saponins. CONCLUSION: Chemical fingerprinting and quantitative analysis identified most of the common saponins for the quality control of P. notoginseng products such as the XST injection.
Background Xuesaitong (XST) injection, consisting of total saponins from Panax notoginseng, was widely used for the treatment of cardio- and cerebro-vascular diseases in China. This study develops a simple and global quality evaluation method for the quality control of XST. Methods High performance liquid chromatography-ultraviolet detection (HPLC-UV) was used to identify and quantify the chromatographic fingerprints of the XST injection. Characteristic common peaks were identified using HPLC with photo diode array detection/electrospray ionization tandem mass spectrometry (HPLC-PDA/ESI-MS.sup.n.sup.). Results Representative fingerprints from ten batches of samples showed 27 'common saponins' all of which were identified and quantified using ten reference saponins. Conclusion Chemical fingerprinting and quantitative analysis identified most of the common saponins for the quality control of P. notoginseng products such as the XST injection.
Xuesaitong (XST) injection, consisting of total saponins from Panax notoginseng, was widely used for the treatment of cardio- and cerebro-vascular diseases in China. This study develops a simple and global quality evaluation method for the quality control of XST. High performance liquid chromatography-ultraviolet detection (HPLC-UV) was used to identify and quantify the chromatographic fingerprints of the XST injection. Characteristic common peaks were identified using HPLC with photo diode array detection/electrospray ionization tandem mass spectrometry (HPLC-PDA/ESI-MSn). Representative fingerprints from ten batches of samples showed 27 'common saponins' all of which were identified and quantified using ten reference saponins. Chemical fingerprinting and quantitative analysis identified most of the common saponins for the quality control of P. notoginseng products such as the XST injection.
ArticleNumber 9
Audience Academic
Author Shi, Peiying
Fan, Xiaohui
Yao, Hong
Shao, Qing
AuthorAffiliation 1 Pharmaceutical Informatics Institute, Zhejiang University, Hangzhou 310058, China
AuthorAffiliation_xml – name: 1 Pharmaceutical Informatics Institute, Zhejiang University, Hangzhou 310058, China
Author_xml – sequence: 1
  givenname: Hong
  surname: Yao
  fullname: Yao, Hong
  email: fanxh@zju.edu.cn
  organization: Pharmaceutical Informatics Institute, Zhejiang University, Hangzhou 310058, China. fanxh@zju.edu.cn
– sequence: 2
  givenname: Peiying
  surname: Shi
  fullname: Shi, Peiying
– sequence: 3
  givenname: Qing
  surname: Shao
  fullname: Shao, Qing
– sequence: 4
  givenname: Xiaohui
  surname: Fan
  fullname: Fan, Xiaohui
BackLink https://www.ncbi.nlm.nih.gov/pubmed/21349173$$D View this record in MEDLINE/PubMed
BookMark eNp1Uktv1DAQjlARfcCRK4o4wCnFj9iJL6jVCmilRVSCcrX8yq6rrL21k4r-eya7ZbULQj54ZvzNN5755rQ4CjG4oniN0TnGLf-Am1pULat5xSvxrDjZ-Ud79nFxmvMdQowy2r4ojgmmtcANPSnCbOlW3qi-7HxYuLROPgxglSrY8n5U4Axq8A8OAqp_zD6XsStVeQPurzLEIS58yA4S1smtVQJsDOWYJ4qrm_msuv25odrYX7-_LJ53qs_u1dN9Vtx-_vRjdlXNv325nl3OK80RHypbE9Ji1RjbdMrYjoHNLO5a0iiOLSbcMGpUa4SjnOqWcdFoQq0TrGm1c_SsuN7y2qjuJDS1UulRRuXlJhDTQqo0eNM7iVwHBTgTXENZo7UgujaECsa6WlsFXB-3XOtRr5w1LgxJ9Qekhy_BL-UiPkiKGCE1BoKLLYH28T8Ehy8mruSknZy0k1wKoHj_9IcU70eXB7ny2bi-V8HFMQOQN7xpGwrIt38h7-KYQLssBSIUhEcIQOdb0ELBBHzoItQ1cOy0DLBgnYf4JWEYEQKKQMK7vYSlU_2wzLEfJ7XzIbDaAk2KOSfX7drESE4L-09jb_aHu0P_2VD6G1P46Is
CitedBy_id crossref_primary_10_1016_j_jep_2019_02_035
crossref_primary_10_1155_2015_165679
crossref_primary_10_1002_jssc_201801161
crossref_primary_10_3724_SP_J_1123_2020_10011
crossref_primary_10_1016_j_jep_2016_08_032
crossref_primary_10_1002_jssc_201500037
crossref_primary_10_1186_s13020_019_0262_9
crossref_primary_10_3390_molecules17055836
crossref_primary_10_1016_j_jgr_2017_04_005
crossref_primary_10_1039_C3MB70581A
crossref_primary_10_1016_j_chroma_2015_05_015
crossref_primary_10_1155_2013_652373
crossref_primary_10_1039_C4AY02277G
crossref_primary_10_1007_s11101_014_9359_z
crossref_primary_10_1016_j_jep_2013_03_043
crossref_primary_10_5142_jgr_2012_36_2_119
crossref_primary_10_3389_fphar_2021_623533
crossref_primary_10_1016_j_chmed_2019_11_002
crossref_primary_10_1016_j_biopha_2022_112887
crossref_primary_10_1016_j_jpha_2022_05_001
crossref_primary_10_1186_s13075_016_0963_8
crossref_primary_10_1016_j_jfda_2015_01_008
crossref_primary_10_1039_D1NP00071C
crossref_primary_10_1016_j_jchromb_2016_01_039
crossref_primary_10_1016_j_foodchem_2020_128243
crossref_primary_10_1080_10408347_2020_1736506
crossref_primary_10_3389_fncel_2021_628115
crossref_primary_10_3390_separations9070163
crossref_primary_10_1080_13880209_2016_1185635
crossref_primary_10_1016_j_ejphar_2018_01_001
Cites_doi 10.1016/j.chroma.2004.09.069
10.1016/j.jchromb.2006.08.002
10.1016/j.chroma.2008.03.052
10.1016/j.chroma.2008.04.040
10.1365/s10337-008-0796-y
10.1016/j.aca.2004.12.064
10.1016/j.jchromb.2007.11.041
10.1002/jssc.200700376
10.1016/j.jpba.2004.12.002
10.1016/j.aca.2007.05.032
10.1002/bmc.813
10.1016/j.jpba.2008.05.027
10.1016/S0021-9673(03)01135-X
10.1002/jssc.200600339
10.1016/j.aca.2009.06.021
10.1016/j.jpba.2008.09.038
10.1016/j.jpba.2006.01.058
10.1016/j.jpba.2007.05.027
10.1016/j.jpba.2005.11.003
10.1016/j.phytochem.2008.01.026
10.1002/rcm.2864
10.1002/jssc.200800552
10.1016/j.chroma.2008.05.082
10.1016/j.phymed.2009.03.016
10.1016/j.jpba.2007.03.032
10.1016/j.phytochem.2008.04.015
ContentType Journal Article
Copyright COPYRIGHT 2011 BioMed Central Ltd.
2011 Yao et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright ©2011 Yao et al; licensee BioMed Central Ltd. 2011 Yao et al; licensee BioMed Central Ltd.
Copyright_xml – notice: COPYRIGHT 2011 BioMed Central Ltd.
– notice: 2011 Yao et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
– notice: Copyright ©2011 Yao et al; licensee BioMed Central Ltd. 2011 Yao et al; licensee BioMed Central Ltd.
DBID NPM
AAYXX
CITATION
3V.
7T5
7TM
7X7
7XB
8FD
8FI
8FJ
8FK
ABUWG
AFKRA
AZQEC
BENPR
CCPQU
DWQXO
FR3
FYUFA
GHDGH
H94
K9.
M0S
P64
PIMPY
PQEST
PQQKQ
PQUKI
PRINS
RC3
7X8
5PM
DOA
DOI 10.1186/1749-8546-6-9
DatabaseName PubMed
CrossRef
ProQuest Central (Corporate)
Immunology Abstracts
Nucleic Acids Abstracts
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Technology Research Database
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni Edition)
ProQuest Central
ProQuest Central Essentials
ProQuest Central
ProQuest One Community College
ProQuest Central
Engineering Research Database
Health Research Premium Collection
Health Research Premium Collection (Alumni)
AIDS and Cancer Research Abstracts
ProQuest Health & Medical Complete (Alumni)
Health & Medical Collection (Alumni Edition)
Biotechnology and BioEngineering Abstracts
Publicly Available Content Database
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
Genetics Abstracts
MEDLINE - Academic
PubMed Central (Full Participant titles)
DOAJ Directory of Open Access Journals
DatabaseTitle PubMed
CrossRef
Publicly Available Content Database
Technology Research Database
ProQuest Central Essentials
Nucleic Acids Abstracts
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
ProQuest Central China
ProQuest Central
Genetics Abstracts
Health Research Premium Collection
Health and Medicine Complete (Alumni Edition)
ProQuest Central Korea
AIDS and Cancer Research Abstracts
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
ProQuest Hospital Collection (Alumni)
Biotechnology and BioEngineering Abstracts
ProQuest Health & Medical Complete
ProQuest One Academic UKI Edition
Immunology Abstracts
Engineering Research Database
ProQuest One Academic
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList CrossRef

MEDLINE - Academic


Publicly Available Content Database

PubMed
Database_xml – sequence: 1
  dbid: DOA
  name: DOAJ Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 2
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 3
  dbid: BENPR
  name: ProQuest Central
  url: https://www.proquest.com/central
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
EISSN 1749-8546
EndPage 9
ExternalDocumentID oai_doaj_org_article_0efdf56596bd42cbb92b4c23955f4bda
oai_biomedcentral_com_1749_8546_6_9
2504177661
A251022606
10_1186_1749_8546_6_9
21349173
Genre Journal Article
GeographicLocations China
GeographicLocations_xml – name: China
GroupedDBID ---
-5E
-5G
-A0
-BR
0R~
29B
2VQ
2WC
3V.
4.4
53G
5GY
5VS
6J9
6PF
7X7
8FI
8FJ
AAFWJ
AAJSJ
AAWTL
ABDBF
ABUWG
ACGFO
ACGFS
ACIHN
ACPRK
ACRMQ
ADBBV
ADINQ
ADUKV
AEAQA
AENEX
AFKRA
AFPKN
AFRAH
AHBYD
AHMBA
AHSBF
AHYZX
ALIPV
ALMA_UNASSIGNED_HOLDINGS
AMKLP
AMTXH
AOIJS
BAPOH
BAWUL
BCNDV
BENPR
BFQNJ
BMC
BPHCQ
BVXVI
C1A
C24
C6C
CCPQU
CS3
DIK
DU5
E3Z
EBD
EBLON
EBS
EJD
ESX
F5P
FYUFA
GROUPED_DOAJ
GS5
GX1
H13
HMCUK
HYE
IAO
IHW
IPNFZ
ITC
M~E
NPM
OK1
P2P
PGMZT
PIMPY
PQQKQ
PROAC
RBZ
RIG
RNS
ROL
RPM
RSV
SMD
SOJ
TUS
UKHRP
UNMZH
WOQ
WOW
~8M
AAYXX
CITATION
AFGXO
ABVAZ
AFNRJ
7T5
7TM
7XB
8FD
8FK
AZQEC
DWQXO
FR3
H94
K9.
P64
PQEST
PQUKI
PRINS
RC3
7X8
5PM
ID FETCH-LOGICAL-b606t-d42281a7cd7facdf51a75d1f827a61d126c53ca8c9e363b85697b23de9578bee3
IEDL.DBID RBZ
ISSN 1749-8546
IngestDate Tue Oct 22 15:01:17 EDT 2024
Tue Sep 17 21:17:10 EDT 2024
Wed May 22 07:17:16 EDT 2024
Sat Aug 17 03:07:05 EDT 2024
Thu Oct 10 15:50:40 EDT 2024
Fri Feb 02 04:27:10 EST 2024
Tue Aug 20 22:02:05 EDT 2024
Thu Sep 12 16:44:22 EDT 2024
Sat Sep 28 07:49:54 EDT 2024
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 1
Language English
License This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-b606t-d42281a7cd7facdf51a75d1f827a61d126c53ca8c9e363b85697b23de9578bee3
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
OpenAccessLink http://dx.doi.org/10.1186/1749-8546-6-9
PMID 21349173
PQID 902313400
PQPubID 54985
PageCount 1
ParticipantIDs doaj_primary_oai_doaj_org_article_0efdf56596bd42cbb92b4c23955f4bda
pubmedcentral_primary_oai_pubmedcentral_nih_gov_3052241
biomedcentral_primary_oai_biomedcentral_com_1749_8546_6_9
proquest_miscellaneous_856767873
proquest_journals_902313400
gale_infotracacademiconefile_A251022606
gale_healthsolutions_A251022606
crossref_primary_10_1186_1749_8546_6_9
pubmed_primary_21349173
PublicationCentury 2000
PublicationDate 2011-02-24
PublicationDateYYYYMMDD 2011-02-24
PublicationDate_xml – month: 02
  year: 2011
  text: 2011-02-24
  day: 24
PublicationDecade 2010
PublicationPlace England
PublicationPlace_xml – name: England
– name: London
PublicationTitle Chinese medicine
PublicationTitleAlternate Chin Med
PublicationYear 2011
Publisher BioMed Central Ltd
BioMed Central
BMC
Publisher_xml – name: BioMed Central Ltd
– name: BioMed Central
– name: BMC
References 14518765 - J Chromatogr A. 2003 Sep 5;1011(1-2):77-87
16962399 - J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Feb 1;846(1-2):32-41
19553096 - Phytomedicine. 2009 Oct;16(10):950-9
18502433 - J Chromatogr A. 2009 Mar 13;1216(11):2156-62
17651936 - J Pharm Biomed Anal. 2007 Sep 21;45(1):38-46
18342344 - Phytochemistry. 2008 May;69(7):1555-64
17238214 - Rapid Commun Mass Spectrom. 2007;21(4):519-28
17385805 - Biomed Chromatogr. 2007 Jul;21(7):735-46
15907618 - J Pharm Biomed Anal. 2005 Jun 1;38(1):45-51
16522361 - J Pharm Biomed Anal. 2006 Aug 28;41(5):1596-601
16343839 - J Pharm Biomed Anal. 2006 Feb 24;40(3):669-78
18678457 - J Pharm Biomed Anal. 2008 Sep 10;48(1):100-4
19160370 - J Sep Sci. 2009 Feb;32(4):613-22
18550076 - J Chromatogr A. 2009 Mar 13;1216(11):2071-8
18395730 - J Chromatogr A. 2008 May 23;1192(1):81-8
18550132 - Phytochemistry. 2008 Aug;69(11):2237-44
18069705 - J Sep Sci. 2008 Jan;31(1):9-15
17586124 - Anal Chim Acta. 2007 Jul 2;594(2):265-73
17536725 - J Sep Sci. 2007 Apr;30(6):813-8
15584233 - J Chromatogr A. 2004 Nov 19;1057(1-2):141-9
18995982 - J Pharm Biomed Anal. 2008 Dec 15;48(5):1361-7
18155974 - J Chromatogr B Analyt Technol Biomed Life Sci. 2008 Feb 1;862(1-2):125-31
19591699 - Anal Chim Acta. 2009 Aug 11;647(2):149-58
17499471 - J Pharm Biomed Anal. 2007 Aug 15;44(4):996-1000
CF Qiao (111_CR17) 2007; 30
S Ding (111_CR18) 2008; 69
XF Jin (111_CR20) 2008; 48
M Dumarey (111_CR23) 2008; 1192
CM Lai (111_CR8) 2006; 40
JB Wan (111_CR6) 2006; 41
L Li (111_CR9) 2005; 536
WJ Kong (111_CR21) 2009; 16
XY Li (111_CR10) 2007; 21
AJ Lau (111_CR2) 2004; 1057
L Li (111_CR3) 2005; 38
C Han (111_CR16) 2008; 862
AJ Lau (111_CR1) 2003; 1011
HL Liu (111_CR11) 2008; 68
M Dan (111_CR13) 2008; 69
CC Teo (111_CR24) 2009; 32
J Guan (111_CR4) 2007; 44
W Li (111_CR22) 2007; 45
World Health Organization (111_CR27) 1991
Y Jiang (111_CR19) 2009; 1216
XY Wang (111_CR7) 2007; 594
XJ Wang (111_CR14) 2008; 31
ECY Chan (111_CR12) 2007; 21
State Food and Drug Administration of China (111_CR28) 2000
YN Ni (111_CR25) 2009; 647
ZM Qian (111_CR5) 2008; 48
AH Liu (111_CR15) 2007; 846
J Li (111_CR26) 2009; 1216
References_xml – volume: 1057
  start-page: 141
  year: 2004
  ident: 111_CR2
  publication-title: J Chromatogr A
  doi: 10.1016/j.chroma.2004.09.069
  contributor:
    fullname: AJ Lau
– volume: 846
  start-page: 32
  year: 2007
  ident: 111_CR15
  publication-title: J Chromatogr B
  doi: 10.1016/j.jchromb.2006.08.002
  contributor:
    fullname: AH Liu
– volume: 1192
  start-page: 81
  year: 2008
  ident: 111_CR23
  publication-title: J Chromatogr A
  doi: 10.1016/j.chroma.2008.03.052
  contributor:
    fullname: M Dumarey
– volume: 1216
  start-page: 2156
  year: 2009
  ident: 111_CR19
  publication-title: J Chromatogr A
  doi: 10.1016/j.chroma.2008.04.040
  contributor:
    fullname: Y Jiang
– volume: 68
  start-page: 1033
  year: 2008
  ident: 111_CR11
  publication-title: Chromatographia
  doi: 10.1365/s10337-008-0796-y
  contributor:
    fullname: HL Liu
– volume: 536
  start-page: 21
  year: 2005
  ident: 111_CR9
  publication-title: Anal Chim Acta
  doi: 10.1016/j.aca.2004.12.064
  contributor:
    fullname: L Li
– volume: 862
  start-page: 125
  year: 2008
  ident: 111_CR16
  publication-title: J Chromatogr B
  doi: 10.1016/j.jchromb.2007.11.041
  contributor:
    fullname: C Han
– volume: 31
  start-page: 9
  year: 2008
  ident: 111_CR14
  publication-title: J Sep Sci
  doi: 10.1002/jssc.200700376
  contributor:
    fullname: XJ Wang
– volume: 38
  start-page: 45
  year: 2005
  ident: 111_CR3
  publication-title: J Pharm Biomed Anal
  doi: 10.1016/j.jpba.2004.12.002
  contributor:
    fullname: L Li
– volume: 594
  start-page: 265
  year: 2007
  ident: 111_CR7
  publication-title: Anal Chim Acta
  doi: 10.1016/j.aca.2007.05.032
  contributor:
    fullname: XY Wang
– volume: 21
  start-page: 735
  year: 2007
  ident: 111_CR10
  publication-title: Biomed Chromatogr
  doi: 10.1002/bmc.813
  contributor:
    fullname: XY Li
– volume: 48
  start-page: 100
  year: 2008
  ident: 111_CR20
  publication-title: J Pharm Biomed Anal
  doi: 10.1016/j.jpba.2008.05.027
  contributor:
    fullname: XF Jin
– volume: 1011
  start-page: 77
  year: 2003
  ident: 111_CR1
  publication-title: J Chromatogr A
  doi: 10.1016/S0021-9673(03)01135-X
  contributor:
    fullname: AJ Lau
– volume: 30
  start-page: 813
  year: 2007
  ident: 111_CR17
  publication-title: J Sep Sci
  doi: 10.1002/jssc.200600339
  contributor:
    fullname: CF Qiao
– volume: 647
  start-page: 149
  year: 2009
  ident: 111_CR25
  publication-title: Anal Chim Acta
  doi: 10.1016/j.aca.2009.06.021
  contributor:
    fullname: YN Ni
– volume-title: Technical Requirements for the Development of Fingerprints of TCM Injections
  year: 2000
  ident: 111_CR28
  contributor:
    fullname: State Food and Drug Administration of China
– volume: 48
  start-page: 1361
  year: 2008
  ident: 111_CR5
  publication-title: J Pharm Biomed Anal
  doi: 10.1016/j.jpba.2008.09.038
  contributor:
    fullname: ZM Qian
– volume: 41
  start-page: 1596
  year: 2006
  ident: 111_CR6
  publication-title: J Pharm Biomed Anal
  doi: 10.1016/j.jpba.2006.01.058
  contributor:
    fullname: JB Wan
– volume-title: Guidelines for the Assessment of Herbal Medicines
  year: 1991
  ident: 111_CR27
  contributor:
    fullname: World Health Organization
– volume: 45
  start-page: 38
  year: 2007
  ident: 111_CR22
  publication-title: J Pharm Biomed Anal
  doi: 10.1016/j.jpba.2007.05.027
  contributor:
    fullname: W Li
– volume: 40
  start-page: 669
  year: 2006
  ident: 111_CR8
  publication-title: J Pharm Biomed Anal
  doi: 10.1016/j.jpba.2005.11.003
  contributor:
    fullname: CM Lai
– volume: 69
  start-page: 1555
  year: 2008
  ident: 111_CR18
  publication-title: Phytochemistry
  doi: 10.1016/j.phytochem.2008.01.026
  contributor:
    fullname: S Ding
– volume: 21
  start-page: 519
  year: 2007
  ident: 111_CR12
  publication-title: Rapid Commun Mass Spectrom
  doi: 10.1002/rcm.2864
  contributor:
    fullname: ECY Chan
– volume: 32
  start-page: 613
  year: 2009
  ident: 111_CR24
  publication-title: J Sep Sci
  doi: 10.1002/jssc.200800552
  contributor:
    fullname: CC Teo
– volume: 1216
  start-page: 2071
  year: 2009
  ident: 111_CR26
  publication-title: J Chromatogr A
  doi: 10.1016/j.chroma.2008.05.082
  contributor:
    fullname: J Li
– volume: 16
  start-page: 950
  year: 2009
  ident: 111_CR21
  publication-title: Phytomedicine
  doi: 10.1016/j.phymed.2009.03.016
  contributor:
    fullname: WJ Kong
– volume: 44
  start-page: 996
  year: 2007
  ident: 111_CR4
  publication-title: J Pharm Biomed Anal
  doi: 10.1016/j.jpba.2007.03.032
  contributor:
    fullname: J Guan
– volume: 69
  start-page: 2237
  year: 2008
  ident: 111_CR13
  publication-title: Phytochemistry
  doi: 10.1016/j.phytochem.2008.04.015
  contributor:
    fullname: M Dan
SSID ssj0053538
Score 2.0805695
Snippet Xuesaitong (XST) injection, consisting of total saponins from Panax notoginseng, was widely used for the treatment of cardio- and cerebro-vascular diseases in...
Abstract Background Xuesaitong (XST) injection, consisting of total saponins from Panax notoginseng , was widely used for the treatment of cardio- and...
Background Xuesaitong (XST) injection, consisting of total saponins from Panax notoginseng, was widely used for the treatment of cardio- and cerebro-vascular...
Abstract Background: Xuesaitong (XST) injection, consisting of total saponins from Panax notoginseng , was widely used for the treatment of cardio- and...
BACKGROUNDXuesaitong (XST) injection, consisting of total saponins from Panax notoginseng, was widely used for the treatment of cardio- and cerebro-vascular...
BACKGROUND: Xuesaitong (XST) injection, consisting of total saponins from Panax notoginseng, was widely used for the treatment of cardio- and cerebro-vascular...
Abstract Background Xuesaitong (XST) injection, consisting of total saponins from Panax notoginseng, was widely used for the treatment of cardio- and...
SourceID doaj
pubmedcentral
biomedcentral
proquest
gale
crossref
pubmed
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
StartPage 9
SubjectTerms Analytical chemistry
Chromatography
Health aspects
High performance liquid chromatography
Mass spectrometry
Saponins
Spectrum analysis
SummonAdditionalLinks – databaseName: DOAJ Directory of Open Access Journals
  dbid: DOA
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3Nj9UgECdmD8aL8du6fnAweiLbQoFyXDduXozPbKLP7I1AATUxdN33XuKf7wBt87oevHijDJAyMwwDDD8Qei0d72qVkI9rqUhLJSUqB43XLlgTPDP5ubf1J7HatB8u-eXBU18pJqzAAxfGndQ-uABehxLWtbS3VlHb9pQpzkNrXXGNGj4tpooN5oznN6zB3Vak462Y0DU7cTLnEUHUjWvuPxezUwbx_9tUH8xVyzjKg4np_B66O3qU-LT05D665eMDdHs9npk_RHHCBMAhb-GlnbwU64xNdPjX3sR8zQyMHmQUgBI8BGzwBXz-xnHYpXDvrYcKV9e-IIUPEad4-W94dfHxjGy-5qZyev35Edqcv_9ytiLjKwvEwuJlR1wCAWuM7J0MpgdeQ5q7JnRUGtG4hoqes950vfJMMNtxoaSlzHkFg916zx6jozhE_xRh1zeGdTW3IqiWN9Y4y5XnXDa-4S6ICqkFt_VVQdTQCeN6SYHhppOkdJKUFlpV6M0kmblaXsB04mbBd0lui7ZzBmiVHrVK_0urKvQqSV2Xy6izFdCn4A6CKgPjKvQ2l0h2AP64N-N1BuBEQtRalDyeVEePBmKrVcLdY2BAK4RnKozsdFxjoh_2W-hQAtPrJKvQk6Jnc58SDB-ss4EiFxq46PSSEn98z-DhYN-T1_bsf3DpGN0pW-yU0PY5Otpd7_0L8NF29mUejn8AxcE64A
  priority: 102
  providerName: Directory of Open Access Journals
– databaseName: PubMed Central
  dbid: RPM
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Jb9QwFLbaHhAXVPZQFh8QnNJJ4tiOj2VENUIMGgkG9WZ5bSu1zjCL1J_Ps5OMmnLj5sSL_PwWb-99Rugjt7QpREQ-LrjI64pXuUhO44X1WnlHVHrubf6DzZb1twt6cYDoEAuTnPaNvj4NN7en4foq-Vaubs1k8BObLOZTkNE480wO0SEnZNiid-aXElDhAUyzYRNYcYu8oTXLWS4S9C-pYYtCHgS434zmpQTf_6-RvjdLjT0o701J58foSb-WxGddn5-iAxeeoUfz_rb8OQoDGgD26fAunuFFL2esgsV_diqkADMwd_CjgybBrccKL-DzDod2Gx29Nw4qrNauwwhvA46e8pd4tvg-zZe_U1MpPf_5Ai3Pv_6azvL-fYVcw7Zlm9sI_1Uqbiz3ylhPIU1t6ZuKK1basmKGEqMaIxxhRDeUCa4rYp0ANdfOkZfoKLTBvUbYmlKRpqCaeVHTUiurqXCU8tKV1HqWITEabbnqsDRkRLce54Ciycg0GZkmmRQZ-jRwZl8tbV0a9rDgl8i3UdvpR7u-lL38yMJ5oJRRwTTQb7QWla5NRQSlvtZWZehD5LrswlD3-i_PYCEIQgwDl6HPqUS0ANBjo_pABhiJiKU1KnkyiI7sTcNGioi4R8B0Zgjvc0Gn40WNCq7dbYCgCKPXcJKhV52c7WkaxDdDfCSBI6LHOaBFCTa815o3_13zBD3uTtSrvKrfoqPteufewZJsq98nFfwL0r04Ew
  priority: 500
  providerName: National Library of Medicine
– databaseName: ProQuest Central
  dbid: BENPR
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1La9wwEBZtAqWX0ned9KFDaU8itmXJ1qkkIWEp3bC03ZKbkCwpKRR7sw_Iz--M_CBOoTdZD6PRjEYjafQNIR9LJ6pUIfJxWipW5GXOVHQaT12wJnhuYri3-YWcLYuvl-Ky983Z9G6Vg06Mitq1NZ6RHykEKuMgcV9WNwyDRuHlah9B4yHZz7MCb2n3T84uFt8HVSy4iKGswepWrBKFHEA2K3k05jHJ1L3X7n8mi1TE8v9XY99ZsqbulHfWp_On5ElvWNLjThKekQe-eU4ezfur8xekGaABaIgneXighy7P1DSO3uxME1-bge6DjA6nhLaBGrqAz1vatFv0-t54aLBa-w4wvG0ous1f0dni2ylb_oq_iun5j5dkeX7283TG-mALzMIeZsscYoFlpqxdGUztgoC0cFmo8tLIzGW5rAWvTVUrzyW3lZCqtDl3XsGct97zV2SvaRv_hlBXZ4ZXqbAyqEJk1jgrlBeizHwmXJAJUZPR1qsOWEMj1PW0BCRAI6c0ckpLrRLyaeDM2CzuYyp5v-IJ8m3y75jRrq90Pyt16gNQKoWSFuivrVW5LeqcKyFCYZ1JyAfkuu7epI7KQB-DVQgSDQOXkM-xBqoD6HFt-lcNMBIIrDWpeTiIju71xEaPUp0QOpbCBMdbG9P4drcBghBTryp5Ql53cjbShGh8sN2GknIigROipyXN7-uIIQ5qHo23g_926pA87o7Qc5YXb8nedr3z78AG29r3_Uz7C1fkMfw
  priority: 102
  providerName: ProQuest
Title Chemical fingerprinting and quantitative analysis of a Panax notoginseng preparation using HPLC-UV and HPLC-MS
URI https://www.ncbi.nlm.nih.gov/pubmed/21349173
https://www.proquest.com/docview/902313400
https://search.proquest.com/docview/856767873
http://dx.doi.org/10.1186/1749-8546-6-9
https://pubmed.ncbi.nlm.nih.gov/PMC3052241
https://doaj.org/article/0efdf56596bd42cbb92b4c23955f4bda
Volume 6
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3Nb9MwFLfYJiEuiG_CoPiA4BSRxLEdH9tpU1XRqWIUVVwsO7YHEnLG2kr8-Tw7HyzlyCkftqM8vw8_Pz__jNA7bmiViYB8nHGRlgUvUhGTxjPjtHKWqHjc2_KSzdflYkM3f0GSDlbw84p9BJdZpBUtWcpScYROioBwHqbls2-9yaWExiOrh6o9mOZh84Nd7T9Hg1HE7P_XMt8ZmsZpk3fGoYtH6GHnQOJpy_HH6J71T9D9ZbdE_hT5HgIAuxixC4G7kNqMlTf41175uKsMbBy8aPFIcOOwwit4_I19swvZ3VsLDW5ubQsM3ngc0uOv8Xz16Sxdf42fivfLq2dofXH-5WyedocqpBrmKrvUBMyvXPHacKdq4yjcU5O7quCK5SYvWE1JrapaWMKIrigTXBfEWAG6ra0lz9Gxb7x9ibCpc0WqjGrmRElzrYymwlLKc5tT41iCxKi35U0LoCEDpPW4BLRLBk7JwCnJpEjQ-54zQ7M4X6nYYcVZ4Nvo2_EFyJDstE9m1gGljAqmgf5aa1Hosi6IoNSV2qgEvQ1cl-3e00Hp5RS8P5Bc6LgEfYg1gtrDH9eq270APREAtEY1T3vRkZ092EoRYPYI2MsE4aEUFDmszihvm_0WCArYeRUnCXrRytlAU0Ddg2k1lPCRBI6IHpf4H98jVjiY8-CkvfoPVpyiB20gvUiL8jU63t3u7RvwxHZ6go74hk_QyXS6uFrAdXZ-ufo8iXGNSdTQSQyf_QES8zdZ
link.rule.ids 108,230,315,733,786,790,870,891,2115,12083,21416,24965,27955,27956,31752,31753,33777,33778,43343,43838,53825,53827,76167,76168
linkProvider BioMedCentral
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lb9QwELagSMAF8SyhQH1AcLK6iWM7PqFSUS2wW1Wii3qz7NguSCjZ7kPi5zPjZKOmSNwcPyKPZzwe2-NvCHmnvKgmGpGPJ0qzslAF08lpfOKjszFwm8K9zc_kdFF-vRSXvW_Ouner3OnEpKh9W-MZ-ZFGoDIOEvdxec0waBRervYRNO6SeyXnJYq5uhz2W4KLFMgabG7NKlHKHcRmJY-GPCaZvvXW_fdoiUpI_v_q6xsL1tiZ8sbqdPqYPOrNSnrcycETcic0T8n9eX9x_ow0O2AAGtM5Hh7nocMztY2n11vbpLdmoPkgo0MpoW2klp7D5x_atBv0-V4HaLBchQ4uvG0oOs1f0en57IQtfqRfpfT8-3OyOP18cTJlfagF5mAHs2EekcByq2qvoq19FJAWPo9VoazMfV7IWvDaVrUOXHJXCamVK7gPGma8C4G_IHtN24SXhPo6t7yaCCejLkXurHdCByFUHnLho8yIHo22WXawGgaBrsclwH-DnDLIKSONzsj7HWeGZmkXU8nbFT8h30b_Thnt6sr0c9JMQgRKpdDSAf21c7pwZV1wLUQsnbcZOUSum-5F6qAKzDHYhCDPMHAZ-ZBqoDKAHte2f9MAI4GwWqOaBzvRMb2WWJtBpjNCh1KY3nhnY5vQbtdAECLqVYpnZL-Ts4EmxOKDzTaUqJEEjogelzS_fiYEcVDyaLq9-m-nDsmD6cV8ZmZfzr4dkIfdYXrBivI12dustuENWGMb9zbNub-9WTOD
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lb9QwELagSBUXxLtpgfqA4BS6iWMnPraF1QLdagUsqrhYdmwXRJVs9yHx85lxHtosR25ObEcaz8MzzsxnQl7nlhcjicjHo1zGWZqnsQxJ4yPrjfaO6XDd2_RSTObZpyt-1UIKYS0MJhC6let-LL_bLkK_CZYbGuXvk4X1jcIX4gScahkXPBOxiOVdcg8ic4Fx2JezH51R5oyHS637oR3c5u70nbr3m8F2FVD9_7XdW5vXMLFya6caPyQPWheTnjYy8YjccdVjsj9taX1Cqg4kgPpwpodHe5j8THVl6e1GV6HuDKwgvGgQS2jtqaYzePxDq3qN-d8rBxMWS9dAh9cVxQT6azqZXZzH8-_hU6E9_fqUzMcfvp1P4vbahdhANLOOLaKCJTovbe51aT2HNreJL9Jci8QmqSg5K3VRSscEMwUXMjcps06C9hvn2DOyV9WVOyDUlolmxYgb4WXGE6Ot4dJxnicu4daLiMjBaqtFA7GhEPR62AOsV8gphZxSQsmIvOk4008LEU0hdgeeId8G3w4v6uW1avVTjZwHSgWXwgD9pTEyNVmZMsm5z4zVETlGrqumOrU3C-oU_EOQbVi4iLwNI9AwoIzqtr4BVgIhtgYjjzrRUa3FWCmJQHwMLGpEaN8Lqo7_b3Tl6s0KCEJ0vSJnEXneyFlPE-LyQeANPflAAgdED3uqXz8DmjgYfHTjDv-DFcdkf_Z-rC4-Xn4-IvebU_c0TrMXZG-93LiX4LatzaugkH8BIVtBbQ
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Chemical+fingerprinting+and+quantitative+analysis+of+a+Panax+notoginseng+preparation+using+HPLC-UV+and+HPLC-MS&rft.jtitle=Chinese+medicine&rft.au=Yao%2C+Hong&rft.au=Shi%2C+Peiying&rft.au=Shao%2C+Qing&rft.au=Fan%2C+Xiaohui&rft.date=2011-02-24&rft.issn=1749-8546&rft.eissn=1749-8546&rft.volume=6&rft.issue=1&rft_id=info:doi/10.1186%2F1749-8546-6-9&rft.externalDBID=n%2Fa&rft.externalDocID=10_1186_1749_8546_6_9
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1749-8546&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1749-8546&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1749-8546&client=summon