Protective Effects of Polydatin Against Dementia-Related Disorders

Dementia is a collection of symptoms affecting a person’s cognition. Dementia is debilitating, and therefore, finding an effective treatment is of utmost importance. Resveratrol, which exhibits neuroprotective effects, has low bioavailability. However, its glucoside polydatin is more bioavailable. H...

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Bibliographic Details
Published inCurrent neuropharmacology Vol. 19; no. 2; pp. 127 - 135
Main Author Tang, Kim San
Format Journal Article
LanguageEnglish
Published United Arab Emirates Bentham Science Publishers Ltd 01.01.2021
Bentham Science Publishers
Subjects
Alzheimer Disease - drug therapy
Dementia
Glucosides - pharmacology
Glucosides - therapeutic use
Humans
Lewy Body Disease
Stilbenes - pharmacology
Stilbenes - therapeutic use
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Summary:Dementia is a collection of symptoms affecting a person’s cognition. Dementia is debilitating, and therefore, finding an effective treatment is of utmost importance. Resveratrol, which exhibits neuroprotective effects, has low bioavailability. However, its glucoside polydatin is more bioavailable. Here, the evidence that supports the protective role of polydatin against dementia- related diseases such as Alzheimer’s disease, vascular dementia, alcohol-related dementia, and Lewy body dementias is presented. The beneficial effects of polydatin from a mechanistic perspective are specifically emphasized in this review. Future directions in this area of research are also discussed.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1570-159X
1875-6190
DOI:10.2174/1570159X18666200611144825