Effects of ultraviolet irradiation on natural killer cell function in systemic lupus erythematosus

In vitro irradiation with long wavelength ultraviolet light (UV-A), in clinically relevant dosages, of a natural killer cell line containing cell preparations from 17 control subjects reduced natural killer cell cytotoxicity with the cell line K562 as target. The spontaneous function of natural kill...

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Bibliographic Details
Published inAnnals of the Rheumatic Diseases Vol. 51; no. 6; pp. 726 - 730
Main Authors Nived, O, Johansson, I, Sturfelt, G
Format Journal Article
LanguageEnglish
Published London BMJ Publishing Group Ltd and European League Against Rheumatism 01.06.1992
Elsevier BV
BMJ
Elsevier Limited
Subjects
Adolescent
Adult
Biological and medical sciences
Blood Sedimentation
Cell Line
Cytotoxicity, Immunologic
Cytotoxicity, Immunologic - radiation effects
Female
Humans
Killer Cells, Natural
Killer Cells, Natural - physiology
Killer Cells, Natural - radiation effects
Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic - blood
Lupus Erythematosus, Systemic - drug therapy
Lupus Erythematosus, Systemic - immunology
Male
Medical sciences
Middle Aged
Prednisolone
Prednisolone - administration & dosage
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
Ultraviolet Rays
Ultraviolet Rays - adverse effects
Human
Skin disease
Long wave
Cytotoxicity
Autoimmune disease
In vitro
Natural killer cell
Ultraviolet radiation
T-Lymphocyte
Systemic disease
Irradiation
Lupus erythematosus
Disseminated
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Summary:In vitro irradiation with long wavelength ultraviolet light (UV-A), in clinically relevant dosages, of a natural killer cell line containing cell preparations from 17 control subjects reduced natural killer cell cytotoxicity with the cell line K562 as target. The spontaneous function of natural killer cells from 12 patients with systemic lupus erythematosus (SLE) correlated inversely with the one hour erythrocyte sedimentation rate, but not with glucocorticoid doses. After UV-A exposure, natural killer cells from patients with SLE exert either increased or decreased cytotoxicity, and the direction of change is inversely correlated with the spontaneous natural killer cell function.
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ISSN:0003-4967
1468-2060
DOI:10.1136/ard.51.6.726