In vivo antimalarial activity of ethanolic leaf extract of Stachytarpheta cayennensis

• Published in: Indian journal of pharmacology Vol. 40; no. 3; pp. 111 - 113
• Main Authors: Okokon, Jude E, Ettebong, Ette, Antia, Bassey S
• Format: Journal Article
• Language: English
• Published: India Medknow Publications on behalf of Indian Pharmacological Society 01.06.2008; Medknow Publications and Media Pvt. Ltd; Medknow Publications & Media Pvt. Ltd; Medknow Publications
• Subjects: Alcohol; Alcohol, Denatured; Antimalarial; Antimalarials; Care and treatment; Erythrocytes; Health aspects; Immunization; Infection; Malaria; Medicine, Botanic; Medicine, Herbal; Physiological aspects; Plasmodium berghei; Prevention; Properties; Stachytarpheta cayennensis; Thin films; Verbena; Nigeria; Antimalarial; Plasmodium berghei; Stachytarpheta cayennensis; malaria
• ISSN: 0253-7613; 1998-3751
• DOI: 10.4103/0253-7613.42303

Objective: To evaluate the in vivo antiplasmodial activity of the ethanol leaf extract of Stachytarpheta cayennensis   in the treatment of various ailment in Niger Delta region of Nigeria, in Plasmodium berghei infected mice. Materials and Methods: The ethanolic leaf extract of Stachytarpheta cayennensis (90-270 mg/kg/day) was screened for blood schizonticidal activity against chloroquine sensitive Plasmodium berghei berghei in mice. The schizonticidal effect during early and established infections was investigated. Result: Stachytarpheta cayennensis (90-270 mg/kg/day) exhibited significant (P < 0.05) blood schizonticidal activity both in 4-day early infection test and in established infection with a considerable mean survival time comparable to that of the standard drug, chloroquine, 5 mg/kg/day. Conclusion: The leaf extract possesses significant (P < 0.05) antiplasmodial activity which confirms it′s use in folkloric medicine in the treatment of malaria.