Definition of age-dependent reference values for the diameter of the common bile duct and pancreatic duct on MRCP: a population-based, cross-sectional cohort study

• Published in: Gut Vol. 72; no. 9; pp. 1738 - 1744
• Main Authors: Beyer, Georg, Kasprowicz, Florian, Hannemann, Anke, Aghdassi, Ali, Thamm, Patrick, Volzke, Henry, Lerch, Markus M, Kühn, Jens-Peter, Mayerle, Julia
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group Ltd and British Society of Gastroenterology 01.09.2023; BMJ; BMJ Publishing Group LTD; BMJ Publishing Group
• Series: Original research
• Subjects: Abdomen; Age; Aged; Bile ducts; cholangiocarcinoma; Cholangiopancreatography, Magnetic Resonance; Cholecystectomy; Cohort analysis; Cohort Studies; Common Bile Duct; Common Bile Duct - pathology; Cross-Sectional Studies; diagnostic and therapeutic endoscopy; Disease; Endoscopy; epidemiology; Gallbladder; Gallstones; Humans; Investigations; Liver cirrhosis; Magnetic Resonance Imaging; Pancreas; Pancreatic cancer; Pancreatic Ducts; Pancreatic Ducts - diagnostic imaging; Pancreatic Ducts - pathology; Pancreatitis; Physiology; Population studies; Population-based studies; Reference Values; Sensitivity analysis; Ultrasonic imaging; Germany; Magnetic Resonance Imaging; epidemiology; pancreatic cancer; cholangiocarcinoma; diagnostic and therapeutic endoscopy
• ISSN: 0017-5749; 1468-3288; 1468-3288
• DOI: 10.1136/gutjnl-2021-326106

ObjectiveChanges of the pancreaticobiliary ducts herald disease. Magnetic resonance cholangiopancreatography (MRCP) allows accurate duct visualisation. Data on reliable upper reference ranges are missing.DesignCross-sectional whole body MRI data from the population-based Study of Health in Pomerania were analysed. The width of the common bile duct (CBD) and the pancreatic duct (PD) was determined. We aimed to describe the distribution of physiological duct diameters on MRCP in a population of healthy subjects and to identify factors influencing duct size.ResultsAfter excluding pre-existing pancreaticobiliary conditions, CBD and PD diameters from 938 and 774 healthy individuals, respectively, showed a significant increase with age (p<0.0001) and exceeded the conventional upper reference limit of normal in 10.9% and 18.2%, respectively. Age-dependent upper reference limits of duct diameters were delineated with non-parametric quantile regression, defined as 95th percentile: for CBD up to 8 mm in subjects <65 years and up to 11 mm in subjects ≥65 years. For the PD reference diameters were up to 3 mm in subjects <65 years and up to 4 mm in subjects ≥65 years.ConclusionsThis is the first population-based study delineating age-adjusted upper reference limits of CBD and PD on MRCP. We showed that up to 18.2% of healthy volunteers would have needed diagnostic workup, if the conventional reference values were used. The utilisation of the adapted reference levels may help to avoid unnecessary investigations and thus to reduce healthcare expenditure and test-related adverse events.