Tumor-associated macrophages: potential therapeutic strategies and future prospects in cancer

• Published in: Journal for immunotherapy of cancer Vol. 9; no. 1; p. e001341
• Main Authors: Li, Chunxiao, Xu, Xiaofei, Wei, Shuhua, Jiang, Ping, Xue, Lixiang, Wang, Junjie
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group LTD 01.01.2021; BMJ Publishing Group
• Subjects: Adults; Antineoplastic Agents - pharmacology; Antineoplastic Agents - therapeutic use; Bacteria; Bone marrow; Cancer; Cell Polarity; Chemokines; Cytokines; Genotype & phenotype; Growth factors; Humans; Immunotherapy; Kinases; Liver; Lymphocytes; Neoplasms - drug therapy; Neoplasms - pathology; Phagocytosis; Prognosis; Proteins; Review; Stem cells; System theory; Transcription factors; Tumor Microenvironment; Tumor-Associated Macrophages - drug effects; Tumor-Associated Macrophages - pathology; macrophages; immunotherapy; tumor microenvironment

Macrophages are the most important phagocytes in vivo. However, the tumor microenvironment can affect the function and polarization of macrophages and form tumor-associated macrophages (TAMs). Usually, the abundance of TAMs in tumors is closely associated with poor prognosis. Preclinical studies hav...