Tumor-associated macrophages: potential therapeutic strategies and future prospects in cancer

Macrophages are the most important phagocytes in vivo. However, the tumor microenvironment can affect the function and polarization of macrophages and form tumor-associated macrophages (TAMs). Usually, the abundance of TAMs in tumors is closely associated with poor prognosis. Preclinical studies hav...

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Published inJournal for immunotherapy of cancer Vol. 9; no. 1; p. e001341
Main Authors Li, Chunxiao, Xu, Xiaofei, Wei, Shuhua, Jiang, Ping, Xue, Lixiang, Wang, Junjie
Format Journal Article
LanguageEnglish
Published England BMJ Publishing Group LTD 01.01.2021
BMJ Publishing Group
Subjects
Adults
Antineoplastic Agents - pharmacology
Antineoplastic Agents - therapeutic use
Bacteria
Bone marrow
Cancer
Cell Polarity
Chemokines
Cytokines
Genotype & phenotype
Growth factors
Humans
Immunotherapy
Kinases
Liver
Lymphocytes
Neoplasms - drug therapy
Neoplasms - pathology
Phagocytosis
Prognosis
Proteins
Review
Stem cells
System theory
Transcription factors
Tumor Microenvironment
Tumor-Associated Macrophages - drug effects
Tumor-Associated Macrophages - pathology
macrophages
immunotherapy
tumor microenvironment
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Summary:Macrophages are the most important phagocytes in vivo. However, the tumor microenvironment can affect the function and polarization of macrophages and form tumor-associated macrophages (TAMs). Usually, the abundance of TAMs in tumors is closely associated with poor prognosis. Preclinical studies have identified important pathways regulating the infiltration and polarization of TAMs during tumor progression. Furthermore, potential therapeutic strategies targeting TAMs in tumors have been studied, including inhibition of macrophage recruitment to tumors, functional repolarization of TAMs toward an antitumor phenotype, and other therapeutic strategies that elicit macrophage-mediated extracellular phagocytosis and intracellular destruction of cancer cells. Therefore, with the increasing impact of tumor immunotherapy, new antitumor strategies to target TAMs are now being discussed.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
CL, XX and SW are joint first authors.
ISSN:2051-1426
2051-1426
DOI:10.1136/jitc-2020-001341