Humoral immune response to vaccines in patients with rheumatoid arthritis treated with tocilizumab: results of a randomised controlled trial (VISARA)

• Published in: Annals of the rheumatic diseases Vol. 74; no. 5; pp. 818 - 822
• Main Authors: Bingham, Clifton O, Rizzo, Warren, Kivitz, Alan, Hassanali, Azra, Upmanyu, Ruchi, Klearman, Micki
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group LTD 01.05.2015; BMJ Publishing Group
• Series: Extended Report
• Subjects: Adolescent; Adult; Antibodies, Monoclonal, Humanized - immunology; Antibodies, Monoclonal, Humanized - therapeutic use; Antigens; Antirheumatic Agents - immunology; Antirheumatic Agents - therapeutic use; Arthritis, Rheumatoid - drug therapy; Arthritis, Rheumatoid - immunology; Clinical and Epidemiological Research; Female; Humans; Hypothesis testing; Immunity, Humoral - immunology; Immunoglobulins; Male; Methotrexate - immunology; Methotrexate - therapeutic use; Middle Aged; Mortality; Pneumococcal Infections - prevention & control; Pneumococcal Vaccines - immunology; Streptococcus pneumoniae; Tetanus; Tetanus - prevention & control; Tetanus Toxoid - immunology; Vaccines; Young Adult; Rheumatoid Arthritis; Methotrexate; Vaccination
• ISSN: 0003-4967; 1468-2060
• DOI: 10.1136/annrheumdis-2013-204427

Objective To evaluate the effect of tocilizumab (TCZ), an interleukin 6 receptor inhibitor, on humoral immune responses to immunisations in patients with rheumatoid arthritis (RA). Methods Patients with RA with inadequate response/intolerance to one or more anti-tumour necrosis factor-α agents were randomly assigned (2:1) to TCZ 8 mg/kg intravenously every 4 weeks plus methotrexate (MTX) or MTX alone up until week 8. Serum was collected before vaccination at week 3, antibody titres were evaluated at week 8, and then all patients received TCZ+MTX through week 20. End points included proportion of patients responding to ≥6/12 pneumococcal polysaccharide vaccine (PPV23) serotypes (primary) and proportions responding to tetanus toxoid vaccine (TTV; secondary) at week 8. Results 91 patients were randomised. At week 8, 60.0% of TCZ+MTX and 70.8% of MTX patients responded to ≥6/12 PPV23 serotypes, with insufficient evidence for any difference in treatments (10.8% (95% CI −33.7 to 12.0)), and 42.0% and 39.1%, respectively, responded to TTV. Two of three TCZ+MTX patients with non-protective baseline TTV antibody titres achieved protective levels by week 8. The safety profile of TCZ was consistent with previous reports. Conclusions Short-term TCZ treatment does not significantly attenuate humoral responses to PPV23 or TTV. To maximise vaccine response, patients should be up to date with immunisations before starting TCZ treatment. ClinicalTrials.gov identifier NCT01163747.