A Y chromosomal influence on prostate cancer risk: the multi-ethnic cohort study

• Published in: Journal of medical genetics Vol. 40; no. 11; pp. 815 - 819
• Main Authors: Paracchini, S, Pearce, C L, Kolonel, L N, Altshuler, D, Henderson, B E, Tyler-Smith, C
• Format: Journal Article
• Language: English
• Published: London BMJ Publishing Group Ltd 01.11.2003; BMJ; BMJ Publishing Group LTD; BMJ Group
• Subjects: Aged; Analysis; association study; Biological and medical sciences; Cancer patients; Care and treatment; Case-Control Studies; Chromosomes; Chromosomes, Human, Y - physiology; Cohort Studies; DNA; Ethnicity; Female; Gene expression; Genetic aspects; Genetic Markers - genetics; Genetic Predisposition to Disease - epidemiology; Genetic research; Haplotypes - genetics; Hawaii-Los Angeles Multiethnic Cohort Study; Health aspects; Health risk assessment; Humans; Male; Mass spectrometry; MEC; Medical genetics; Medical research; Medical sciences; Middle Aged; Nephrology. Urinary tract diseases; Odds Ratio; Original; Phylogeny; Population; Prostate cancer; Prostatic Neoplasms - classification; Prostatic Neoplasms - epidemiology; Prostatic Neoplasms - ethnology; Prostatic Neoplasms - genetics; Risk Factors; Scientific imaging; Studies; Tumors of the urinary system; Urinary tract. Prostate gland; Y chromosome; United States; United Kingdom; Hawaii; Los Angeles California; Urinary system disease; Prostate disease; Cohort study; Risk factor; Risk; Malignant tumor; Male genital diseases; Prostate cancer; Ethnic group
• ISSN: 0022-2593; 1468-6244; 1468-6244
• DOI: 10.1136/jmg.40.11.815

Background: A Y chromosomal role in prostate cancer has previously been suggested by both cytogenetic findings and patterns of Y chromosomal gene expression. We took advantage of the well established and stable phylogeny of the non-recombining segment of the Y chromosome to investigate the association between Y chromosomal DNA variation and prostate cancer risk. Methods: We examined the distribution of 116 Y lineages in 930 prostate cancer cases and 1208 controls from four ethnic groups from a cohort study in Hawaii and California. Results: One lineage, found only among the Japanese group in our study, was associated with a statistically significant predisposition to prostate cancer (odds ratio (OR) = 1.63; 95% confidence interval (CI) 1.07 to 2.47), and, in particular, to high severity disease in younger individuals (OR = 3.89; 95% CI 1.34 to 11.31). Conclusions: This finding suggests that a Y chromosomal factor contributes significantly to the development of prostate cancer in Japanese men.