Epidemiological, clinical features and susceptibility pattern of shigellosis in the buea health district, Cameroon

Shigellosis is an acute invasive enteric infection caused by bacteria belonging to the genus Shigella; it is clinically manifested by bloody diarrhoea. Shigellosis is endemic in many developing countries including Cameroon and also occurs in epidemics causing considerable morbidity and mortality. Th...

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Published inBMC research notes Vol. 5; no. 1; p. 54
Main Authors Njunda, Anna L, Assob, Jules Cn, Nsagha, Dickson S, Kamga, Henri Lf, Awafong, Maghah P, Weledji, Elroy P
Format Journal Article
LanguageEnglish
Published England BioMed Central Ltd 21.01.2012
BioMed Central
BMC
Subjects
Antibacterial agents
Antibiotics
Antimicrobial agents
Bacteria
Cameroon
Care and treatment
Causes of
Children
Clinical features
Disease
Drinking water
Drug resistance
Epidemiology
Health aspects
Health sciences
Methods
Shigella
Shigellosis
Susceptibility pattern
Cameroon
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Summary:Shigellosis is an acute invasive enteric infection caused by bacteria belonging to the genus Shigella; it is clinically manifested by bloody diarrhoea. Shigellosis is endemic in many developing countries including Cameroon and also occurs in epidemics causing considerable morbidity and mortality. This study evaluated the epidemiological and clinical features of Shigella and the resistance pattern of isolates to commonly used antibiotics in the Buea Health District in Cameroon, from April to August, 2010. Of the 223 stool samples cultured, 10 (4.5%) yielded Shigella species. Isolation rate was observed to be more in children below 15 years (7.89%), and also higher in rural areas (6.35%). All 10 isolates showed resistance to at least two antibiotics and 9 (90%) were multi-drug resistant. The highest resistance rates were encountered with cotrimoxazole (90%) and amoxicillin (80%). Least resistance was observed with azithromycin (10%). Shigellosis is more prevalent in children below 15 years in the Buea District. There is a high level of resistance to most of the antibiotics used for the treatment of shigellosis including extended-spectrum beta-lactamases (ESBLs) as well as evidence of resistance to quinolones. Azithromycin was found to be the drug of choice for shigellosis in this setting.
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ISSN:1756-0500
1756-0500
DOI:10.1186/1756-0500-5-54